Journal ArticleDOI
Short-term inhibition of fatty acid biosynthesis in isolated hepatocytes by mono-aromatic compounds
Anton C. Beynen,Math J.H. Geelen +1 more
Reads0
Chats0
TLDR
It is proposed that all of the drugs exert an inhibitory action at the level of acetyl-CoA carboxylase, the enzyme generally considered to catalyse the rate-limiting step in hepatic fatty acid synthesis.About:
This article is published in Toxicology.The article was published on 1982-01-01. It has received 15 citations till now. The article focuses on the topics: Fatty acid synthesis & Fatty acid.read more
Citations
More filters
Journal ArticleDOI
Inhibition of corn acetyl-CoA carboxylase by cyclohexanedione and aryloxyphenoxypropionate herbicides☆
James D. Burton,James D. Burton,John W. Gronwald,John W. Gronwald,David A. Somers,David A. Somers,Burle G. Gengenbach,Burle G. Gengenbach,Donald L. Wyse,Donald L. Wyse +9 more
TL;DR: Cyclohexanedione and aryloxyphenoxypropionate herbicides are potent inhibitors of acetyl-CoA carboxylase in corn, a susceptible species; whereas the enzyme from pea, a tolerant species, was tolerant to the herbicides.
Journal ArticleDOI
Inhibition of Acetyl-CoA Carboxylase Activity by Haloxyfop and Tralkoxydim
Jacob Secor,Csaba Cséke +1 more
TL;DR: Results suggest that acetyl-CoA carboxylase, which catalyzes the first committed step in fatty acid biosynthesis, may be the target of these herbicides, contrary to an earlier report suggesting that aryloxyphenoxypropionate herbicides do not inhibit acetyl.
Inhibition of Acetyl-CoA Carboxylase Activity by Haloxyfop and
Jacob Secor,Csaba Cséke +1 more
TL;DR: This paper showed that CoA carboxylase from maize (Zea mays L) is inhibited by nanomolar concentrations of haloxyfop, an aryloxyphenoxypropionate, and tralkoxydim, a cyclohexanedione herbicide.
Journal ArticleDOI
Enantioselective degradation and ecotoxicity of the chiral herbicide diclofop in three freshwater alga cultures.
TL;DR: It was concluded that the enantioselective degradation and toxicity of chiral herbicides may result in their ecotoxicological effects being difficult to predict and that specific attention should thus be paid to currently used racemic pesticides as less active or inactive enantiomers may pose higher ecological risks.
Journal ArticleDOI
Role of hepatic carbonic anhydrase in de novo lipogenesis
Christopher J. Lynch,H Fox,Stacy A. Hazen,Bruce A. Stanley,Susanna J. Dodgson,Kathryn F. LaNoue +5 more
TL;DR: A role for carbonic anhydrase in hepatic de novo lipogenesis at the level of pyruvate carboxylation is indicated by measuring [1-14C]acetate incorporation into total lipids, fatty acids and non-saponifiable lipids in freshly isolated rat hepatocytes.
References
More filters
Journal ArticleDOI
The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.
TL;DR: The present studies support the concept that malonyl-CoA plays a pivotal role in the coordination of hepatic fatty acid synthesis and oxidation, and the ketogenic effect of glucagon on liver appears to be manifested in large part through the ability of the hormone to reduce the tissue maloneyl- CoA concentration.
Book ChapterDOI
Acetyl coenzyme A carboxylase.
Lane,Moss J,Polakis Se +2 more
TL;DR: This chapter discusses the molecular properties of acetyl-CoA carboxylases from animal, bacterial, and plant cells and focuses on the regulation of catalytic activity.
Journal Article
Action of sodium salicylate and related compounds on tissue metabolism in vitro
TL;DR: Salicylates stimulate the respiratory rate of an acceptor-deficient system and inhibit fatty acid oxidation of rat liver mitochondria and enhance the liberation of inorganic phosphate from ATP.
Journal ArticleDOI
The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by α-Cyano-4-hydroxycinnamate and related compounds
TL;DR: Studies with whole-cell preparations incubated in vitro indicate that alpha-cyano-4-hydroxycinnamate oralpha-cyanocinnamate can be used to specifically inhibit mitochondrial pyruvate transport within cells and thus alter the metabolic emphasis of the preparation.
Journal ArticleDOI
Short-term Hormonal Control of Hepatic Lipogenesis
TL;DR: The ability to keep large amounts of triacylglycerols on board would not be useful, however, if it were not possible to quickly and efficiently stop diverting foodstuffs into triacyglycerol formation and to start utilizing these compounds to provide the energy necessary to synthesize ATP as mentioned in this paper.
Related Papers (5)
Inhibition of fatty acid biosynthesis in isolated bean and maize chloroplasts by herbicidal phenoxy-phenoxypropionic acid derivatives and structurally related compounds
Hans H. Hoppe,Helga Zacher +1 more