Journal ArticleDOI
Chlorophyll and chromosome breakage
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TLDR
It is observed that while a crude aqueous extract of Indian spinach leaf significantly reduced genotoxic effects, chlorophyll alone was ineffective and induced a significantly high frequency of chromosome breaks in bone marrow cells of mice on oral administration.Abstract:
Increased consumption of green vegetables in the diet has been associated with protection against carcinogenic effects and related mutagenic and clastogenic (chromosome breaking) activity of genotoxic agents. Chlorophyll, present in all green plant parts, has been suggested to be a major protective factor in the process. We have, however, observed that while a crude aqueous extract of Indian spinach leaf significantly reduced genotoxic effects, chlorophyll alone was ineffective. On the other hand, chlorophyll, both as an aqueous extract from the leaf and in a purified commercial form, induced a significantly high frequency of chromosome breaks in bone marrow cells of mice on oral administration. The crude aqueous extract of the leaf was non-toxic. The protective activity of the crude leaf extract may be attributed to the total effect of the interaction between different components, in which the clastogenicity of chlorophyll has been neutralized.read more
Citations
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Chlorophylls and their Derivatives Used in Food Industry and Medicine
TL;DR: A comprehensive overview of the health benefits and potential medicinal applications of these pigments and the future directions of research in these fields are provided.
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Validation of single cell gel assay in human leukocytes with 18 reference compounds.
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Determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino by liquid chromatography-mass spectrometry.
TL;DR: A high performance liquid chromatography-mass spectrometry (HPLC-MS) method for determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino, a traditional Chinese herb possessing vital biological activities.
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The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point.
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Effect of chlorophyllin on chromium trioxide-induced micronuclei in polychromatic erythrocytes in mouse peripheral blood.
TL;DR: The absence of a protective effect by CHL in the MN-PCE induction by CrO(3) at 48h, show that CHL has action only on one of the times of MN induction and suggests the possible action of CrO (3) by two different mechanisms, and not byCHL time-limited in vivo.
References
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Journal ArticleDOI
Studies on the antimutagenic activities of garlic extract.
TL;DR: Results obtained in preliminary experiments with Chinese hamster ovary cells suggest that the antimutagenic properties of garlic extract are not restricted to procaryotic cells.
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Suppression of 7,12-dimethylbenz[a]anthracene-induced chromosome aberrations in rat bone marrow cells by vegetable juices
TL;DR: The present results may suggest that some vegetables, such as onion, suppress chemically induced cancer and Glutathione also suppressed DMBA-induced CA.
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Differential protection of chlorophyllin against clastogenic effects of chromium and chlordane in mouse bone marrow in vivo.
TL;DR: The anticlastogenic activity of sodium-copper-chlorophyllin was tested against two known clastogens, chromium(VI) oxide and the pesticide chlordane, both of which occur as environmental toxicants.
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Modification of clastogenicity of three known clastogens by garlic extract in mice in vivo.
TL;DR: The clastogenicity of all three mutagens were reduced significantly in the animals which had been given garlic extract as dietary supplement and may be attributed to the interaction with the different components of the extract.
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Relative efficiency of Phyllanthus emblica fruit extract and ascorbic acid in modifying lead and aluminium-induced sister-chromatid exchanges in mouse bone marrow
TL;DR: PFE afforded a more pronounced protective effect than AA in counteracting the genotoxicity induced by both Al and Pb: This difference was significant with Pb.