Journal ArticleDOI
Chlorophyll and chromosome breakage
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TLDR
It is observed that while a crude aqueous extract of Indian spinach leaf significantly reduced genotoxic effects, chlorophyll alone was ineffective and induced a significantly high frequency of chromosome breaks in bone marrow cells of mice on oral administration.Abstract:
Increased consumption of green vegetables in the diet has been associated with protection against carcinogenic effects and related mutagenic and clastogenic (chromosome breaking) activity of genotoxic agents. Chlorophyll, present in all green plant parts, has been suggested to be a major protective factor in the process. We have, however, observed that while a crude aqueous extract of Indian spinach leaf significantly reduced genotoxic effects, chlorophyll alone was ineffective. On the other hand, chlorophyll, both as an aqueous extract from the leaf and in a purified commercial form, induced a significantly high frequency of chromosome breaks in bone marrow cells of mice on oral administration. The crude aqueous extract of the leaf was non-toxic. The protective activity of the crude leaf extract may be attributed to the total effect of the interaction between different components, in which the clastogenicity of chlorophyll has been neutralized.read more
Citations
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Iron-chlorophyllin-mediated conversion of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2(NHOH)) into its nitroso derivative
TL;DR: The suppression of the mutagenicity of Trp-P-2(NHOH) is ascribable to the oxidative function of Fe-chlorophyllin, coupled with its ability to form complex formation with the planar surface of the heterocyclic amine molecules.
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Anticlastogenicity of chlorophyllin in the different cell cycle phases in cultured mammalian cells
Priscilla D. Negraes,Berenice Quinzani Jordão,Veronica Elisa Pimenta Vicentini,Mário Sérgio Mantovani +3 more
TL;DR: The results demonstrate a greater protective effectiveness of Chln against EMS during G2/S, and the latter in reversing DNA damage induced by ethyl methane sulfonate (EMS).
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Differential Protection of A and B Chlorophyll in MMC-mediated Induction of Chromatid and Isochromatid Breaks in Human Lymphocytes Culture.
Girlene de Cássia Bez,Berenice Quinzani Jordão,Veronica Elisa Pimenta Vicentini,Mário Sérgio Mantovani +3 more
TL;DR: The anticlastogenic data obtained suggest that the molecule types used acted similarly with the same efficacy, mainly in the phases G1 and S of cell cycle, where chromosome breaks commonly occur.
Journal ArticleDOI
Antigenotoxic properties of chlorophyll b against cisplatin-induced DNA damage and its relationship with distribution of platinum and magnesium in vivo.
Juliana Mara Serpeloni,Bruno Lemos Batista,José Pedro Friedmann Angeli,Gustavo Rafael Mazzaron Barcelos,Maria de Lourdes Pires Bianchi,Fernando Barbosa,Lusânia Maria Greggi Antunes +6 more
TL;DR: Results indicate that consumption of CLb-rich foods may diminish the adverse health effects induced by cDDP exposure, and indicates that genotoxic effects produced by c DDP may not be related to Pt accumulation and distribution.
Journal ArticleDOI
Chlorophyllin Antimutagenesis Mechanisms under Different Treatment Conditions in the Micronucleus Assay in V79 Cells
L.G.L. Rampazo,Berenice Quinzani Jordão,Veronica Elisa Pimenta Vicentini,Mário Sérgio Mantovani +3 more
TL;DR: The data obtained in the simultaneous treatments suggested desmutagenic action whereas the pre and post treatments suggested bioantimutagenic activity of chlorophyllin in V79 cells.
References
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Journal ArticleDOI
Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells.
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Diet in the Epidemiology of Cancer of the Colon and Rectum
TL;DR: The decrease in risk the authors found associated with frequent ingestion of vegetables, and especially cabbage, Brussels sprouts, and broccoli, is consistent with the decreased numbers of tumors observed in animals challenged with carcinogens and fed compounds found in these same vegetables.
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Dietary inhibitors of mutagenesis and carcinogenesis.
TL;DR: In this chapter, inhibitors of mutagenesis and carcinogenesis that can arise as components of diet have been reviewed and most of the inhibitors have been demonstrated to be effective against a specific class of mutagens or carcinogens.
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