Journal ArticleDOI
Clinical and biochemical features of depression in Parkinson's disease.
Reads0
Chats0
TLDR
Level of CSF 5-hydroxyindoleacetic acid was lowest in parkinsonian patients with major depression and was related to psychomotor retardation and loss of self-esteem and the effects of thyrotropin-releasing hormone and L-dopa on plasma growth hormone and prolactin were examined.Abstract:
Among 49 consecutive patients with Parkinson’s disease, 40% were depressed according to DSM-III; they had major depression or dysthymic disorder accompanied by sleep disturbance, fatigue, psychomotor retardation, loss of self-esteem, and excessive guilt. During a 1 0-day dopamine-free period, lumbar puncture was performed to measure the metabolites of dopamine, serotonin, and norepinephrine. Patients were given an overnight dexamethasone suppression test, and the effects of thyrotropin-releasing hormone and L-dopa on plasma growth hormone and prolactin were examined. Level of CSF 5-hydroxyindoleacetic acid was lowest in parkinsonian patients with major depression and was related to psychomotor retardation and loss of self-esteem. (Am J Psychiatry 143:756-759, 1986)read more
Citations
More filters
Journal ArticleDOI
Depression and Parkinson's disease: a review.
TL;DR: Neurobiological investigations suggest that depression in Parkinson's disease may be mediated by dysfunction in mesocortical/prefrontal reward, motivational, and stress-response systems.
Journal ArticleDOI
Reliability, validity, and clinical correlates of apathy in Parkinson's disease.
Sergio E. Starkstein,Helen S. Mayberg,Thomas J. Preziosi,Paula L. Andrezejewski,Ramón Leiguarda,Robert G. Robinson +5 more
TL;DR: Results suggest that apathy is a frequent finding in PD, is significantly associated with specific cognitive impairments, and may have a different mechanism than depression.
Journal ArticleDOI
Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
Maria C. Rodriguez-Oroz,Maria C. Rodriguez-Oroz,Marjan Jahanshahi,Paul Krack,Paul Krack,Irene Litvan,R. Macías,Erwan Bezard,Jose A. Obeso,Jose A. Obeso +9 more
TL;DR: In this paper, the authors discuss the motor, cognitive, and psychiatric manifestations associated with the dopaminergic deficiency in the early phase of the parkinsonian state and the different circuits implicated, and propose distinct mechanisms to explain the wide clinical range of PD symptoms at the time of diagnosis.
Journal ArticleDOI
Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample.
Lydia A. Chwastiak,Dawn M. Ehde,Laura E. Gibbons,Mark D. Sullivan,James D. Bowen,George H. Kraft +5 more
TL;DR: Clinicians should evaluate depression in patients with recent diagnoses of multiple sclerosis, major changes in functioning, or limited social support, because of the high prevalence rates of depression seen in patients seen in specialty clinics.
References
More filters
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal ArticleDOI
National Institute of Mental Health diagnostic interview schedule: Its history, characteristics, and validity.
TL;DR: In this article, a new interview schedule allows lay interviewers or clinicians to make psychiatric diagnoses according to DSM-III criteria, Feighner criteria, and Research Diagnostic Criteria.
Journal ArticleDOI
A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility.
Bernard J. Carroll,Michael Feinberg,John F. Greden,Janet Tarika,A. Ariav Albala,Roger F. Haskett,Norman McI. James,Ziad Kronfol,Naomi E. Lohr,Meir Steiner,Jean Paul de Vigne,Elizabeth A. Young +11 more
TL;DR: Abnormal DST results were found with similar frequency among outpatients and inpatients with melancholia; but they were not related to age, sex, recent use of psychotropic drugs, or severity of depressive symptoms.
Journal ArticleDOI
Depression, intellectual impairment, and Parkinson disease
TL;DR: The results confirm the high incidence of depression in PD and suggest that depression in Parkinson patients may be accompanied by mild intellectual impairment and inattention which is independent of the severity of the illness.
Journal ArticleDOI
Human growth hormone. clinical measurement, response to hypoglycemia and suppression by corticosteroids.
TL;DR: The unusually high species specificity of human growth hormone has been further demonstrated by immunologic studies, in which antigenic similarity and biologic effectiveness have closely paralleled one another among various mammalian species.