Clinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: results from the SIMI-COVID-19 study of the Italian Society of Internal Medicine (SIMI).
Elena Corradini,Paolo Ventura,Walter Ageno,Chiara Cogliati,Maria Lorenza Muiesan,Domenico Girelli,Mario Pirisi,Antonio Gasbarrini,Paolo Angeli,Patrizia Rovere Querini,Emanuele Bosi,Moreno Tresoldi,Roberto Vettor,Marco Cattaneo,Fabio Piscaglia,Antonio Brucato,Stefano Perlini,Paolo Martelletti,Roberto Pontremoli,Massimo Porta,Pietro Minuz,Oliviero Olivieri,Giorgio Sesti,Gianni Biolo,Damiano Rizzoni,Gaetano Serviddio,Francesco Cipollone,Davide Grassi,Roberto Manfredini,Guido Moreo,Antonello Pietrangelo +30 more
TLDR
In this paper, the authors conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU, and identified PaO2/FiO2 ratio at admission and comorbidity as the main alert signs to inform clinical decisions and resource allocation.Abstract:
During the COVID-19 2020 outbreak, a large body of data has been provided on general management and outcomes of hospitalized COVID-19 patients. Yet, relatively little is known on characteristics and outcome of patients managed in Internal Medicine Units (IMU). To address this gap, the Italian Society of Internal Medicine has conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU. This study assessed 3044 COVID-19 patients at 41 referral hospitals across Italy from February 3rd to May 8th 2020. Demographics, comorbidities, organ dysfunction, treatment, and outcomes including death were assessed. During the study period, 697 patients (22.9%) were transferred to intensive care units, and 351 died in IMU (death rate 14.9%). At admission, factors independently associated with in-hospital mortality were age (OR 2.46, p = 0.000), productive cough (OR 2.04, p = 0.000), pre-existing chronic heart failure (OR 1.58, p = 0.017) and chronic obstructive pulmonary disease (OR 1.17, p = 0.048), the number of comorbidities (OR 1.34, p = 0.000) and polypharmacy (OR 1.20, p = 0.000). Of note, up to 40% of elderly patients did not report fever at admission. Decreasing PaO2/FiO2 ratio at admission was strongly inversely associated with survival. The use of conventional oxygen supplementation increased with the number of pre-existing comorbidities, but it did not associate with better survival in patients with PaO2/FiO2 ratio < 100. The latter, significantly benefited by the early use of non-invasive mechanical ventilation. Our study identified PaO2/FiO2 ratio at admission and comorbidity as the main alert signs to inform clinical decisions and resource allocation in non-critically ill COVID-19 patients admitted to IMU.read more
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PCSK9 Inhibition During the Inflammatory Stage of SARS-CoV-2 Infection
Eliano Pio Navarese,Przemysław Podhajski,Paul A. Gurbel,Klaudyna Grzelakowska,Eleonora Ruscio,Udaya S. Tantry,Przemysław Magielski,Aldona Kubica,Piotr Niezgoda,Piotr Adamski,Roman Junik,Grzegorz K. Przybylski,Marta Pilaczyńska-Cemel,Manali Rupji,Giuseppe Specchia,Jarosław Pinkas,Robert Gajda,Diana A. Gorog,Felicita Andreotti,Jacek Kubica +19 more
TL;DR: In this paper , the authors investigated the impact of PCSK9 inhibition vs placebo on clinical and laboratory outcomes in patients with severe COVID-19 in patients randomized to receive a single 140mg subcutaneous injection of evolocumab or placebo.
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Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein
Manuela Rizzi,Martina Costanzo,Stelvio Tonello,Erica Matino,Francesco G. Casciaro,Alessandro Croce,Eleonora Rizzi,Erika Zecca,Anita R. Pedrinelli,Veronica Vassia,Raffaella Landi,Mattia Bellan,Luigi Mario Castello,Rosalba Minisini,Venkata Ramana Mallela,Gian Carlo Avanzi,Mario Pirisi,Daniele Lilleri,Pier Paolo Sainaghi +18 more
TL;DR: B baseline IP-10 and CRP after 7 days of hospitalization could be useful in driving clinical decisions tailored to the expected disease trajectory in hospitalized COVID-19 patients.
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Comparison of the characteristics, morbidity and mortality of COVID-19 between first and second/third wave in a hospital setting in Lombardy: a retrospective cohort study
Francesca Leidi,G. Boari,Ottavio Scarano,Benedetta Mangili,Giulia Gorla,Andrea Corbani,Beatrice Accordini,F. Napoli,Chiara Ghidelli,Giulia Archenti,Daniele Turini,Michele Saottini,Vittoria Guarinoni,Giulia Ferrari-Toninelli,F. Manzoni,Silvia Bonetti,Giulia Chiarini,Paolo Malerba,Federico Braglia-Orlandini,Gianluca Bianco,Cristina Faustini,Claudia Agabiti-Rosei,Carolina De Ciuceis,Damiano Rizzoni +23 more
TL;DR: In this article , the authors conducted a retrospective cohort study at Montichiari Hospital (Brescia, Italy) to better understand the determinants of outcome in two different COVID-19 outbreaks.
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Factors Associated With COVID-19 Hospitalizations and Deaths in French Nursing Homes.
Anne-Laure Couderc,Florian Correard,Zeinab Hamidou,Emilie Nouguerède,Robin Arcani,Joris Weiland,Anais Courcier,Pierre Caunes,Priscilla Clot-Faybesse,Patrick Gil,Charlotte Berard,Charlène Miola,Julie Berbis,Patrick Villani,Aurélie Daumas +14 more
TL;DR: In this paper, the authors describe the clinical characteristics and management of residents in French nursing homes with suspected or confirmed coronavirus disease 2019 (COVID-19) and to determine the risk factors for COVID19-related hospitalization and death in this population.
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Low eGFR Is a Strong Predictor of Worse Outcome in Hospitalized COVID-19 Patients.
Antonio Mirijello,Pamela Piscitelli,Angela de Matthaeis,Michele Inglese,Maria Maddalena D’Errico,Valentina Massa,Antonio Greco,Andrea Fontana,Massimiliano Copetti,Lucia Florio,Maurizio Leone,Michele Prencipe,Filippo Aucella,Salvatore De Cosmo +13 more
TL;DR: In this paper, the authors evaluated the impact of reduced eGFR on the composite outcome of admission to ICU and death in a sample of consecutive COVID-19 hospitalized patients.
References
More filters
Journal ArticleDOI
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Safiya Richardson,Safiya Richardson,Jamie S. Hirsch,Jamie S. Hirsch,Mangala Narasimhan,James M. Crawford,Thomas McGinn,Thomas McGinn,Karina W. Davidson,Karina W. Davidson,Douglas P. Barnaby,Douglas P. Barnaby,Lance B Becker,John Chelico,John Chelico,Stuart L. Cohen,Stuart L. Cohen,Jennifer Cookingham,Kevin Coppa,Michael A Diefenbach,Andrew J. Dominello,Joan Duer-Hefele,Louise Falzon,Jordan Gitlin,Negin Hajizadeh,Negin Hajizadeh,Tiffany G. Harvin,David Hirschwerk,Eun Ji Kim,Eun Ji Kim,Zachary Kozel,Lyndonna Marrast,Lyndonna Marrast,Jazmin N. Mogavero,Gabrielle A. Osorio,Michael Qiu,Theodoros P. Zanos +36 more
TL;DR: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area and assesses outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death.
Journal ArticleDOI
Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
Journal ArticleDOI
Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy.
TL;DR: Since then, the number of cases identified in Italy has rapidly increased, mainly in northern Italy, but all regions of the country have reported having patients with COVID-19, and Italy now has the second largest number of CO VID-19 cases and also has a very high case-fatality rate.
Journal ArticleDOI
Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review.
W. Joost Wiersinga,Andrew Rhodes,Allen C. Cheng,Sharon J. Peacock,Sharon J. Peacock,Hallie C. Prescott +5 more
TL;DR: This review discusses current evidence regarding the pathophysiology, transmission, diagnosis, and management of COVID-19, the novel severe acute respiratory syndrome coronavirus 2 pandemic that has caused a worldwide sudden and substantial increase in hospitalizations for pneumonia with multiorgan disease.
Journal ArticleDOI
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia.
Carlos Salama,Jian Han,Linda Yau,W. Reiss,Benjamin Kramer,Jeffrey D. Neidhart,Gerard J. Criner,Emma Kaplan-Lewis,Rachel Baden,Lavannya Pandit,Miriam L Cameron,Julia Garcia-Diaz,Victoria Chávez,Martha Mekebeb-Reuter,Ferdinando Lima de Menezes,Reena Shah,Maria F. González-Lara,Beverly Assman,Jamie Freedman,Shalini V. Mohan +19 more
TL;DR: In hospitalized patients with Covid-19 pneumonia who were not receiving mechanical ventilation, tocilizumab reduced the likelihood of progression to the composite outcome of mechanical ventilation or death, but it did not improve survival.