Clinical frailty scale and mortality in COVID-19: A systematic review and dose-response meta-analysis.
Raymond Pranata,Joshua Henrina,Michael Anthonius Lim,Sherly Lawrensia,Emir Yonas,Rachel Vania,Ian Huang,Antonia Anna Lukito,Ketut Suastika,RA Tuty Kuswardhani,Siti Setiati +10 more
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TLDR
In this paper, the authors performed a systematic literature search from several electronic databases up until 8 September 2020 and reported that increase in CFS was associated with increase in mortality in a linear fashion, and the potential for a nonlinear relationship based on ORs of each quantitative clinical frailty scale was examined using restricted cubic splines with a three-knots model.About:
This article is published in Archives of Gerontology and Geriatrics.The article was published on 2021-03-01 and is currently open access. It has received 123 citations till now.read more
Citations
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The degree of frailty as a translational measure of health in aging
TL;DR: In this paper, the authors explore how age-related damage and decline in repair result in cellular and molecular deficits that scale up to tissue, organ and system levels, where they are jointly expressed as frailty.
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Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a systematic review and meta-analysis.
TL;DR: In this article, a meta-analysis aimed to evaluate the prognostic performance of elevated lactate dehydrogenase (LDH) in patients with COVID-19, and the outcome of interest was composite poor outcome, defined as a combined endpoint of mortality, severity, need for invasive mechanical ventilation and need for intensive care unit care.
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Impact of comorbidity burden on mortality in patients with COVID-19 using the Korean health insurance database.
TL;DR: In this article, the authors investigated the impact of comorbidity burden on mortality in patients with coronavirus disease (COVID-19) and found that an ACCI threshold > 3.5 yielded the best cut-off point for predicting mortality.
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Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis
TL;DR: In this article, a systematic review and meta-analysis aimed to assess whether low serum 25-hydroxyvitamin D (25-OHD) level is associated with susceptibility to COVID-19, severity, and mortality.
Journal ArticleDOI
Delirium and Mortality in Coronavirus Disease 2019 (COVID-19) - A Systematic Review and Meta-analysis.
Raymond Pranata,Ian Huang,Ian Huang,Michael Anthonius Lim,Emir Yonas,Rachel Vania,Rachel Vania,Raden Ayu Tuty Kuswardhani +7 more
TL;DR: In this paper, the authors conducted a systematic review and meta-analysis to establish the association between delirium and mortality in older adults with COVID-19 and found that the presence of dementia is associated with increased risk of mortality in hospitalized older adults.
References
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Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - A systematic review, meta-analysis, and meta-regression.
TL;DR: DM was associated with mortality, severe COVID-19, ARDS, and disease progression in patients with CO VID-19 and the association was weaker in studies with median age ≥55 years-old compared to <55 years old, and in prevalence of hypertension ≥25% compared to<25%.
Journal ArticleDOI
The Toughest Triage - Allocating Ventilators in a Pandemic.
TL;DR: The Toughest Triage Of all the medical care that will have to be rationed during the Covid-19 pandemic, the most problematic will be mechanical ventilation.
Journal ArticleDOI
The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study.
Jonathan Hewitt,Jonathan Hewitt,Ben Carter,Arturo Vilches-Moraga,Arturo Vilches-Moraga,Terence J. Quinn,Philip Braude,Alessia Verduri,Lyndsay Pearce,Michael Stechman,Roxanna Short,Angeline Price,Jemima T. Collins,Eilidh Bruce,Alice Einarsson,Frances Rickard,Emma Mitchell,Mark Holloway,James Hesford,Fenella Barlow-Pay,Enrico Clini,Phyo K. Myint,Susan Moug,Kathryn McCarthy,Charlotte Davey,Sheila Jones,Kiah Lunstone,Alice Cavenagh,Charlotte Silver,Thomas Telford,Rebecca G. Simmons,Tarik El Jichi Mutasem,Sandeep Singh,Dolcie Paxton,Will Harris,Norman J. Galbraith,Emma Bhatti,Jenny Edwards,Siobhan Duffy,Carly Bisset,Ross Alexander,Madeline Garcia,Shefali Sangani,Thomas Kneen,Thomas Lee,Aine McGovern,Giovanni Guaraldi +46 more
TL;DR: The prevalence of frailty in patients with COVID-19 who were admitted to hospital is established and its association with mortality and duration of hospital stay is investigated and disease outcomes were better predicted by frailty than either age or comorbidity.
Journal ArticleDOI
Lymphopenia in severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis
TL;DR: A systematic review and meta-analysis showed that lymphopenia on admission was associated with poor outcome in patients with COVID-19 and the association between lymphocyte count and composite poor outcome was affected by age.
Journal ArticleDOI
The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects.
Clara Bonanad,Sergio García-Blas,Francisco José Tarazona-Santabalbina,Juan Sanchis,Vicente Bertomeu-González,Lorenzo Fácila,Albert Ariza,Julio Núñez,Alberto Cordero +8 more
TL;DR: A metanalysis with more than half-million of Covid-19 patients from different countries highlights the determinant effect of age on mortality with the relevant thresholds on age >50 and, especially, >60.
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The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study.
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