Cloning of a unique lipase from endothelial cells extends the lipase gene family
Ken-ichi Hirata,Helén L. Dichek,Joseph A. Cioffi,Sungshin Y. Choi,Nicholas J. Leeper,Leah Quintana,Gregory S. Kronmal,Allen D. Cooper,Thomas Quertermous +8 more
Reads0
Chats0
TLDR
Its tissue-restricted pattern of expression and its ability to be expressed by endothelial cells, suggests that endothelial cell-derived lipase may have unique functions in lipoprotein metabolism and in vascular disease.About:
This article is published in Journal of Biological Chemistry.The article was published on 1999-05-14 and is currently open access. It has received 323 citations till now. The article focuses on the topics: Endothelial lipase & Lipoprotein lipase.read more
Citations
More filters
Journal ArticleDOI
New insights into the regulation of HDL metabolism and reverse cholesterol transport.
Gary F. Lewis,Daniel J. Rader +1 more
TL;DR: Progress in understanding of HDL metabolism and Macrophage reverse cholesterol transport will increase the likelihood of developing novel therapies to raise plasma HDL concentrations and promote macrophage RCT and in proving that these new therapeutic interventions prevent or cause regression of atherosclerosis in humans.
Journal ArticleDOI
High Density Lipoproteins and Arteriosclerosis: Role of Cholesterol Efflux and Reverse Cholesterol Transport
TL;DR: High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs.
Journal ArticleDOI
Molecular regulation of HDL metabolism and function: implications for novel therapies
TL;DR: Advances in the understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.
Journal ArticleDOI
White Adipose Tissue as Endocrine Organ and Its Role in Obesity
TL;DR: Understanding of the molecular process that occurs in the adipocyte will provide new tools for the treatment of metabolic abnormalities during obesity and indicate the contribution of adipose tissue during the development of metabolic syndrome.
Journal ArticleDOI
Characterization of the lipolytic activity of endothelial lipase.
TL;DR: Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity that hydrolyzed HDL more efficiently than the other lipoprotein fractions, and LDL was a poor substrate for all of the enzymes.
References
More filters
Journal ArticleDOI
Angiogenesis in cancer, vascular, rheumatoid and other disease
TL;DR: Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
Journal ArticleDOI
Mechanisms of angiogenesis
TL;DR: Understanding of the molecular basis underlying angiogenesis, particularly from the study of mice lacking some of the signalling systems involved, has greatly improved, and may suggest new approaches for treating conditions such as cancer that depend onAngiogenesis.
Journal ArticleDOI
Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries
Luda Diatchenko,Yun-Fai Chris Lau,Aaron P. Campbell,Alex Chenchik,Fauzia Moqadam,Betty C. B. Huang,Sergey Lukyanov,Konstantin A. Lukyanov,Nadya G. Gurskaya,E.D. Sverdlov,Paul D. Siebert +10 more
TL;DR: The results suggest that the SSH technique is applicable to many molecular genetic and positional cloning studies for the identification of disease, developmental, tissue-specific, or other differentially expressed genes.
Journal ArticleDOI
Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.
TL;DR: Observations indicate that endothelial cells can rapidly differentiate on a basement membrane-like matrix and that laminin is the principal factor in inducing this change.
Journal ArticleDOI
Structure of human pancreatic lipase
TL;DR: The structural results are evidence that Ser 152 is the nucleophilic residue essential for catalysis, located in the larger N-terminal domain at the C- terminal edge of a doubly wound parallel β-sheet and part of an Asp-His-Ser triad, which is chemically analogous to, but structurally different from, that in the serine proteases.