Journal ArticleDOI
Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia
TLDR
Significant and positive correlations are found between UFC on the one hand, and the 24 hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other, and significant relationships between those catecholamines and the postdexamethasone UFC and plasma cortisol values are established.Abstract:
In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), free cortisol (UFC), and plasma cortisol. Melancholic patients were characterized by a significantly higher excretion of noradrenaline, dopamine and adrenaline, combined with significantly increased UFC, postdexamethasone plasma cortisol, and UFC values. We found significant and positive correlations between UFC on the one hand, and the 24hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other. By the same token, we established significant relationships between the 24 hr urine excretion of those catecholamines and the postdexamethasone UFC and plasma cortisol values. Cortisol nonsuppressors exhibited a significantly higher excretion of noradrenaline, dopamine and adrenaline, as compared with cortisol suppressors. Dexamethasone administration did not have a significant effect on the urinary output of noradrenaline, dopamine, adrenaline or MHPG.read more
Citations
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Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis
M J Knol,Jos W. R. Twisk,Jos W. R. Twisk,Aartjan T.F. Beekman,Robert J. Heine,Frank J. Snoek,Frans Pouwer +6 more
TL;DR: In this paper, the authors examined the latter association by reviewing the literature and conducting a meta-analysis of longitudinal studies on this topic, concluding that depression may occur as a consequence of having diabetes, but may also be a risk factor for the onset of type 2 diabetes.
Journal ArticleDOI
Depression in diabetic patients: The relationship between mood and glycemic control
TL;DR: Depression is common in both type 1 and type 2 diabetes and has significant effects on the course and outcome of this medical illness, and conventional antidepressant management strategies are effective and the regimen should be tailored to the individual patient.
Journal ArticleDOI
Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression.
Michael Maes,Simon Scharpé,Herbert Y. Meltzer,Eugene Bosmans,Eduard Suy,Joseph R. Calabrese,Paul Cosyns +6 more
TL;DR: Investigating whether severe depression is characterized by increased interleukin-6 (Il-6) activity and whether Il-6 production is related to altered levels of acute phase reactants and to abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis found significant and positive correlations between Il- 6 activity and postdexamethasone cortisol values.
Journal ArticleDOI
The unknown mechanism of the overtraining syndrome: clues from depression and psychoneuroimmunology.
TL;DR: It is proposed that OTS and clinical depression have similar aetiologies, and novel recommendations are proposed for the treatment of overtrained athletes with antidepressant medications, and guidelines are provided for psychological counselling.
Journal ArticleDOI
The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans
Marieke Wichers,Michael Maes +1 more
TL;DR: Administration of cytokines may induce alterations in the brain resembling those found in depressed patients, which leads to the hypothesis that cytokines induce depression by their influence on the 5-HT, noradrenergic and HPA system.
References
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TL;DR: Findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.
Journal ArticleDOI
The dexamethasone suppression test for melancholia.
TL;DR: This review will focus on the most widely studied neuroendocrine disturbance: disinhibition of the hypothalamus-pituitary-adrenal cortex (HPA) system as revealed by the dexamethasone suppression test (DST).
Journal ArticleDOI
Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus.
TL;DR: Intraventricular administration of CRF-OH, previously demonstrated to be considerably less potent in releasing ACTH, did not alter LC firing rates, and data suggest that activation of these central noradrenergic neurons may constitute an integral part of the overall 'stress response' initiated by CRF release.