Journal ArticleDOI
Collagenase activity of the human aorta. A comparison of patients with and without abdominal aortic aneurysms.
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TLDR
The data suggest that endogenous collagenolytic activity may be responsible for aneurysmal expansion and rupture and that this enzyme is localized in the aneurYSmal wall and is inoperative in arteries affected by atherosclerosis.Abstract:
Deficit of collagen may be a precipitating cause of aneurysm formation and expansion. Specimens of aneurysmal wall were obtained from 11 patients who underwent aneurysmectomy. Comparison aortic specimens were obtained from five patients who underwent aortofemoral bypass for occlusive disease. Collagenase activity was determined on the particulate and soluble fractions by the liberation of L-leucine, with bovine collagen as the substrate. Collagenase activity was detectable in the abdominal aortic aneurysms (AAAs) but not in atherosclerotic aorta or fascia. Collagenase activity was restricted to the particulate fraction in patients with AAAs, and it correlated with aneurysm size. These data suggest that (1) endogenous collagenolytic activity may be responsible for aneurysmal expansion and rupture and that (2) this enzyme is localized in the aneurysmal wall and is inoperative in arteries affected by atherosclerosis.read more
Citations
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Elastolytic and Collagenolytic Studies of Arteries: Implications for the Mechanical Properties of Aneurysms
TL;DR: It is concluded that wall integrity depends on intact collagen rather than elastin, and the latter vessels exhibited dramatically greater dilatation and compliance changes after treatment with collagenase, corresponding to the greater tendency of aneurysms to develop in internal and common iliac arteries.
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Evidence for Altered Balance Between Matrix Metalloproteinases and Their Inhibitors in Human Aortic Diseases
TL;DR: MMP expression is markedly increased in AOD and AAA samples, and an imbalance between MMPs and their inhibitors results in similar proteolytic activity, and the eventual formation of aneurysmal or occlusive lesions appears not to result from an ongoing difference in the proteolytics pattern.
Journal ArticleDOI
Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans
Jean-Baptiste Michel,J.L. Martin-Ventura,Jesús Egido,Natzi Sakalihasan,Vladislav Treska,Jes S. Lindholt,Eric Allaire,Unnur Thorsteinsdottir,Gillian Cockerill,Jesper Swedenborg +9 more
TL;DR: Abdominal aortic aneurysm thus represents an accessible spatiotemporal model of human atherothrombotic progression towards clinical events, the study of which should allow further understanding of its pathogenesis and the translation of pathogenic biological activities into diagnostic and therapeutic applications.
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Natural history, pathogenesis, and etiology of thoracic aortic aneurysms and dissections
TL;DR: The ascending and descending aorta appear to have separate underlying disease processor that lead to a weakened vessel wall and an increased susceptibility for dissection.
Journal ArticleDOI
Role of matrix metalloproteinases in abdominal aortic aneurysms
TL;DR: Recent studies using MMP-inhibiting tetracycline derivatives in the elastase-induced rodent model of AAA indicate that metalloproteinase suppression is a feasible and successful approach in the experimental setting.
References
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Progress in treatment of thoracoabdominal and abdominal aortic aneurysms involving celiac, superior mesenteric, and renal arteries.
TL;DR: Of the 82 patients, 77 (94%) survived operation and long-term follow-up was obtained in 95% of cases, 23 performed over five years ago and survival rate both immediately and at six years, were the same.