Showing papers in "Atherosclerosis in 1987"

TL;DR: The location and timing of lesion formation in the mouse is explored in an effort to provide a basis for quantitatively comparing groups of mice, thereby increasing the usefulness of the mouse as an experimental system for atherosclerosis research.

TL;DR: Data support the view that LpA-I might represent the "antiatherogenic" fraction of HDL, and even, when the levels of their total plasma lipids and lipoproteins are normal, atherosclerotic patients are characterized by a different distribution of apo A-I.

TL;DR: Histological sections through the walls of abdominal aortic aneurysms showed scarce and disrupted elastic tissue and elastin content, and the elastinolytic activity of stenotic aorta contained leukocyte elastase as an important component.

TL;DR: Coronary artery intima was always thicker (eccentric thickening) at bifurcations in the half of the circumference opposite to the flow divider, and the remaining part of the coronary arteryintima was less thick (diffuse thickening).

TL;DR: The HDL-lipid levels in mice on atherogenic diet differed over a 3-fold range among the nine groups, and a high degree of correlation was observed, which suggests that HDL- Lipid levels are important in determining atherosclerosis susceptibility in mice.

TL;DR: The prevalence of coronary artery disease was found to increase progressively with the concentration of plasma cholesterol and triglycerides, total cholesterol/HDL cholesterol ratio and the apo-B48/apo-B100 ratio in lipoproteins Sf greater than 60, the relative risk being highest for total cholesterol-rich cholesterol ratio.

TL;DR: Male hamsters were fed a hyperlipidemic diet consisting of standard chow supplemented with 3% cholesterol and 15% commercial butter for 12 months and serum total cholesterol doubled, raised 4-fold after the 4th week and after 10 months attained a 17-fold value.

TL;DR: In this paper, the influence of β 2 -G-I on the serotonin (5-HT) release during platelet aggregation was measured, and it was shown that β 2 G-I completely inhibited the 5-HT release during ADP-induced platelet activation.

TL;DR: Pulsatile velocities and correlations between time-average or maximum instantaneous wall shear rate and intimal thickness had negative slopes, consistent with those obtained earlier using other human arterial bifurcations.

TL;DR: This study suggests that variations in the gene for apo B are associated with the determination of serum cholesterol and triglyceride levels both in patients with type III hyperlipidaemia and in the normal population.

TL;DR: This new method of LDL apheresis can safely reduce LDL-cholesterol to any desired level and will be applicable for the treatment of child and adult family hypercholesterolemic patients with severe coronary heart disease.

TL;DR: The complete amino acid sequence of the liver-synthesized apolipoprotein B (apoB) species, apoB 100, has been derived from cloned cDNA and Cysteine is clustered in the N-terminal 1/10 of the protein, suggesting the presence of a stabilized tertiary structure in this part of the molecule.

TL;DR: A beneficial effect of fish oil on the cardiovascular risk profile was confirmed in this study, however, with this regime changes in total cholesterol, HDL-cholesterol and platelet aggregation are of unlikely clinical importance.

TL;DR: In the extracellular matrix of the fatty streaks and in some areas of the fibrous plaques containing large amounts of subendothelial cells, some interstitial collagen was revealed, an increased amount of type IV, some type V collagen and a lot of fibronectin.

TL;DR: Total serum peroxide levels, expressed as malondialdehyde equivalents were significantly elevated in the fish oil-treated group, which may be due to malondialsdehyde modification of the lipoproteins and may be responsible for the enhanced development of atherosclerosis in these animals.

TL;DR: Preincubation with either EPA or linoleic acid inhibited the saturable binding of LDL, observed with oleic acid and control incubations, and the binding of lipoproteins containing chylomicron remnants was not affected by any of the fatty acids.

TL;DR: Longitudinal analysis found aging, weight gain, vasectomy, menopause, and increased smoking are associated with worsening lipoprotein profiles, while increased alcohol consumption is associated with increased high densitylipoprotein cholesterol (HDL-C).

TL;DR: The terminal C5b-9 neoantigens of the complement complex, S-protein (Vitronectin), C3c, C3d and apolipoprotein B were localized on 16 aortic fibrous plaques using an indirect and double-staining immunoperoxidase method and could ascribe a role to the complement system in atherosclerosis.

TL;DR: Structural evidence is provided to support the hypothesis that nicotine contributes to the pathogenesis of arterial disease in smokers by assessing ultrastructural features of endothelial injury occurring with exposure to nicotine.

TL;DR: In cultured rabbit aortic vascular smooth muscle cells (VSMC), protein kinase C-activating phorbol esters such as TPA and PDBu stimulated DNA synthesis in the presence of 10% cell-free plasma-derived serum, suggesting that protein Kinase C is involved in PDGF-stimulated proliferation of VSMC.

TL;DR: In the prelesional stages of hyperlipidemia the prevalent localization of apolipoprotein B around individual unesterified cholesterol-rich extracellular phospholipid liposomes, progressively accumulating in the subendothelial space, suggests their possible origin from serum-derived lipoproteins.

TL;DR: The published reports on the association between coffee consumption and cholesterol levels are insufficient to warrant public health admonitions against coffee drinking, but it may be of clinical importance in some hypercholesterolemic individuals.

TL;DR: In this paper, the effects of different distending pressures on the permeability of human and dog arterial media to horseradish peroxidase (HRP) were studied.

TL;DR: It is shown how some experimental procedures produce dramatic increases in smooth muscle cell proliferation and, in many cases, subsequent cell migration to the intimal layer.

TL;DR: Short-term, low-dose corticosteroids markedly affect plasma lipid levels in most subjects; however, an increase in total cholesterol may be indicative of a change in VLDL-C and LDL-C as well.

TL;DR: Changes in the surface of LDL, induced by the arterial PG1, lead to increased endocytosis of the lipoprotein and stimulation of lipid synthesis in the macrophages, suggesting that the accessibility of apoB has been altered.

TL;DR: In atherosclerotic lesions of rabbits fed a cholesterol-rich diet, the lipid deposits of foam cells derived from monocytes, smooth muscle and endothelial cells were studied by physical, cytochemical and ultrastructural methods and cholesterol crystals developed within lysosomal lipid bodies usually enclosed in multilamellar structures.

TL;DR: It is concluded that leukocytes play a major role in cuff-induced intimal thickening, and that their products cause endothelial denudation and SMC chemotaxis and Involvement of platelet aggregation in atherogenesis is also suggested.

TL;DR: Observations suggest that increases in CBV after fish oil supplementation are due to changes in vascular tone and not to alterations in blood pressure or blood viscosity.

TL;DR: The antiatherogenic activity of FR34235 (Nilvadipine), a calcium antagonist, was examined in rabbits with carotid arteries sheathed with polyethylene cuffs, and compared with that of nifedipine, verapamil and diltiazem, suggesting that it should be useful for preventing and treating atherosclerosis.