Journal ArticleDOI
Combined chemotherapy and local treatment in the management of intraocular retinoblastoma.
Bénédicte Brichard,Jean Jacques De Bruycker,Patrick De Potter,Bénédicte Neven,Christiane Vermylen,Guy Cornu +5 more
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TLDR
Although 8 out of 21 eyes with group V retinoblastoma may be salvaged after chemoreduction and local therapies, enucleation remained the treatment of choice in those eyes with total retinal detachment and diffuse vitreous seeding.Abstract:
BACKGROUND: To assess the efficacy of chemotherapy (chemoreduction) plus local treatments as an alternative to external beam and enucleation for intraocular retinoblastoma. MATERIALS AND METHODS: A prospective study was performed on 21 patients with retinoblastoma treated in our institution from September 1997 to December 2000 to study the ocular outcome of those 33 eyes. RESULTS: There were 9 unilateral and 12 bilateral retinoblastoma cases. There were 12 eyes with Reese-Ellsworth group I-IV and 21 eyes with group V. Among 33 eyes, nine eyes (27%) were initially managed by enucleation. The remaining 24 eyes (73%) were initially treated with chemoreduction (maximum of six cycles of carboplatin, vincristine, etoposide) or chemothermotherapy. Among those 24 eyes, 20 were successfully treated with local treatments (thermotherapy plus cryotherapy in 16 eyes and thermotherapy plus cryotherapy plus (125)I plaque radiotherapy in 4 eyes), enucleation eventually underwent in two eyes and was proposed but refused in one child with bilateral group V retinoblastoma. With a median follow-up of 21 months, conservative management without external beam radiation was successful in all 12 eyes with group I-IV and in a total of 20/33 eyes (60%). Among the nine cases of unilateral retinoblastoma, eight were enucleated but among the 24 eyes with bilateral retinoblastoma, 19 (79%) were successfully treated with conservative therapy. CONCLUSIONS: It may be possible to eradicate viable tumor in all eyes with Reese-Ellsworth group I-IV retinoblastoma by chemoreduction followed by local treatments. Although 8 out of 21 eyes (38%) with group V retinoblastoma may be salvaged after chemoreduction and local therapies, enucleation remained the treatment of choice in those eyes with total retinal detachment and diffuse vitreous seeding.read more
Citations
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Journal ArticleDOI
Intraocular retinoblastoma: the case for a new group classification.
TL;DR: The case for the creation of a new group classification of intraocular retinoblastoma is argued, based on the natural history and the risk of loss of the eye following primary therapy, against the current Reese-Ellsworth group classification.
Journal ArticleDOI
Update on retinoblastoma.
TL;DR: The reader will be able to identify the risk factors for the development of second cancers in retinoblastoma patients, the types of cancers that these patients develop most commonly, and the precautions that should be taken by patients to decrease their risk.
Journal ArticleDOI
Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity".
Francis L. Munier,Maja Beck-Popovic,Guillermo Chantada,David Cobrinik,Tero Kivelä,Dietmar R. Lohmann,Philippe Maeder,Annette C. Moll,Angel M. Carcaboso,Alexandre Moulin,Paula Schaiquevich,Ciara Bergin,Paul J. Dyson,Susan Houghton,Francesco Puccinelli,Yvan Vial,Marie-Claire Gaillard,Christina Stathopoulos +17 more
TL;DR: This work intends to review the relevant knowledge susceptible to improve the conservative management of retinoblastoma in compliance with the "state of metastatic grace", with particular attention to reviewing how new imaging modalities impact the frontiers of conservative management.
Journal ArticleDOI
Occurrence of sectoral choroidal occlusive vasculopathy and retinal arteriolar embolization after superselective ophthalmic artery chemotherapy for advanced intraocular retinoblastoma.
Francis L. Munier,Maja Beck-Popovic,Aubin Balmer,Marie-Claire Gaillard,Etienne H. Bovey,Stefano Binaghi +5 more
TL;DR: It is suggested that SOAC should be given in one eye only and restricted to advanced cases of retinoblastoma, as an alternative to enucleation and/or external beam radiotherapy.
Journal ArticleDOI
MicroRNAs in retinoblastoma: Potential diagnostic and therapeutic biomarkers.
Khodayar Golabchi,Rahim Soleimani-Jelodar,Nazila Aghadoost,Fatemeh Momeni,Abdullah Moridikia,Javid Sadri Nahand,Aria Masoudifar,Hasan Razmjoo,Hamed Mirzaei +8 more
TL;DR: A variety of tissue‐specific and circulating miRNAs involved in R b pathogenesis which could be used as diagnostic, prognostic, and therapeutic biomarkers in Rb patients are summarized.
References
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Journal ArticleDOI
Chemotherapy Plus Local Treatment in the Management of Intraocular Retinoblastoma
A. Linn Murphree,Judith G. Villablanca,William F. Deegan,Judith K. Sato,Marcio H. Malogolowkin,Anita M. R. Fisher,Ricardo J. Parker,Eddie Reed,Charles J. Gomer +8 more
TL;DR: Thermochemotherapy is successful primary treatment for Reese-Ellsworth group 1 and 2 retinoblastomas and external beam radiotherapy can safely be avoided in the primary treatment of Reese- Ellsworth groups 1 through 4 nondispersed retinOBlastoma.
Journal ArticleDOI
Chemotherapy With Focal Therapy Can Cure Intraocular Retinoblastoma Without Radiotherapy
Brenda L. Gallie,Andrew Budning,Gerrit DeBoer,Jake J. Thiessen,Gideon Koren,Zul Verjee,Victor Ling,Helen S. L. Chan +7 more
TL;DR: This pilot study suggests that most retinoblastomas are curable by combining chemotherapy with cyclosporine therapy, laser therapy, and cryotherapy, without requiring external beam radiotherapy.
Journal ArticleDOI
Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma
TL;DR: Although most of the treated group V eyes could be salvaged with chemotherapy plus radiotherapy, the resultant visual acuity was often poor, and of the 12 surviving children, 5 have aVisual acuity better than l/60 in at least 1 eye.
Journal ArticleDOI
Chemoreduction and local ophthalmic therapy for intraocular retinoblastoma
Debra L. Friedman,Bruce P. Himelstein,Carol L. Shields,Jerry A. Shields,Michael N. Needle,David Miller,Greta R. Bunin,Anna T. Meadows +7 more
TL;DR: In retinoblastoma patients with Reese-Ellsworth eye groups 1, 2, or 3, systemic chemotherapy used with local ophthalmic therapies can eliminate the need for enucleation or EBRT without significant systemic toxicity.
Journal ArticleDOI
Histopathologic risk factors in retinoblastoma: A retrospective study of 172 patients treated in a single institution
F. Khelfaoui,Pierre Validire,Anne Auperin,Erica Quintana,Jean Michon,Helene Pacquement,Laurence Desjardins,Bernard Asselain,Pierre Schlienger,Philippe Vielh,Jean-Louis Dufier,Jean-Michel Zucker,François Doz +12 more
TL;DR: The aim of this retrospective study was to define the histopathologic risk factors for orbital and/or metastatic disease in patients treated by first‐line enucleation.