Combined interferon-alpha 2, rimantadine hydrochloride, and ribavirin inhibition of influenza virus replication in vitro.
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TLDR
Human interferon-alpha 2 interacted additively or synergistically with rimantadine hydrochloride or ribavirin in reducing the yield of clinical isolates of either H3N2 or H1N1 subtype influenza A viruses and inhibited the replication of an influenza B virus to a greater extent than either single agent.Abstract:
Recombinant DNA-produced human interferon-alpha 2 inhibited the replication of influenza A and B viruses in primary rhesus monkey kidney cells (RMK). Human interferon-alpha 2 interacted additively or synergistically with rimantadine hydrochloride or ribavirin in reducing the yield of clinical isolates of either H3N2 or H1N1 subtype influenza A viruses. The combination of human interferon-alpha 2 and ribavirin also inhibited the replication of an influenza B virus to a greater extent than either single agent. In addition to drug concentration, the virus inoculum and duration of culture were important variables in determining the degree of inhibition. Single drugs or combinations did not significantly inhibit the growth of uninfected RMK cells, which indicated that the observed interactions with respect to antiviral activity were not due to cell cytotoxicity.read more
Citations
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References
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A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection
TL;DR: Rimantadine appears to be the drug of choice for the prophylaxis of influenza A, as compared with placebo in a placebo-controlled, double-blind, randomized trial.
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TL;DR: During an influenza outbreak, five days of empirical therapy with amantadine or rimantadines for persons with an influenza-like syndrome should ameliorate clinical symptoms and might decrease spread of virus.
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Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.
TL;DR: Combinations with these antivirals, which are currently being evaluated singly for the therapy of severe forms of herpetic infection, could prove clinically useful if increasing numbers of resistant viral strains are observed.