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Proceedings ArticleDOI

Compact silicon biosensor for the clinical range estimation of blood serum triglycéride

TLDR
A miniaturized biochip with immobilized enzyme integrated with a thin film counter electrode for the estimation of TG in blood serum within the clinical range is developed.
Abstract
Electrolyte Insulator Semiconductor Capacitor (El S CAP) is a transducer that can detect triglycerides (TGs) in blood serum through an enzymatic response that changes the pH of the electrolyte (blood serum). This change in pH is transformed by the EISCAP to a shift in the capacitance-voltage (C-V) characteristics of the device which in turn can be mapped to the amount of TG in blood serum. We have developed a miniaturized biochip with immobilized enzyme integrated with a thin film counter electrode for the estimation of TG in blood serum within the clinical range. The miniaturized devices are tested using blood serum sample to estimate the TG concentration and compared with clinical data.

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References
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Development of an Ion-Sensitive Solid-State Device for Neurophysiological Measurements

TL;DR: The development of an ion-sensitive solid-state device that combines the principles of an MOS transistor and a glass electrode and can be used for measurements of ion activities in electrochemical and biological environments is described.
Journal ArticleDOI

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Journal ArticleDOI

Development, Operation, and Application of the Ion-Sensitive Field-Effect Transistor as a Tool for Electrophysiology

TL;DR: A new solid-state device has been developed that makes it possible to measure ion activities without using a reference electrode and has the properties of both a glass electrode and a field-effect transistor.
Journal ArticleDOI

Basic properties of the electrolyte—SiO 2 —Si system: Physical and theoretical aspects

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Journal ArticleDOI

Lipoprotein lipase-catalyzed hydrolysis of p-nitrophenyl butyrate. Interfacial activation by phospholipid vesicles.

TL;DR: The hypothesis that LpL interacts with lipid interfaces to increase the catalytic activity toward a water-soluble substrate is supported, for interfacial activation, LnL prefers the lipid interface in the gel phase to that in the liquid-crystalline phase.
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