Journal ArticleDOI
Comparison of local and global angular interpolation applied to spectral-spatial EPR image reconstruction.
Kang-Hyun Ahn,Howard J. Halpern +1 more
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TLDR
The cubic B-spline, angular interpolation was preferable to either sinc or linear interpolation methods, and the reduction of background artifacts improves lineshape fitting.Abstract:
Spectral-spatial imagesreconstructed from a small number of projections suffer from streak artifacts that are seen as noise, particularly in the spectral dimension. Interpolation in projection space can reduce artifacts in the reconstructed images. The reduction of background artifacts improves lineshape fitting. In this work, we compared the performances of angular interpolation implemented using linear, cubic B-spline, and sinc methods. Line width maps were extracted from 4-D EPRimages of phantoms using spectral fitting to evaluate each interpolation method and its robustness to noise. Results from experiment and simulation showed that the cubic B-spline, angular interpolation was preferable to either sinc or linear interpolation methods.read more
Citations
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Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance.
TL;DR: Developing more accurate measurements and images of tissue O2 partial pressure (pO2), assumes enormous practical, biological, and medical importance.
Journal ArticleDOI
A Versatile High Speed 250 MHz Pulse Imager for Biomedical Applications.
TL;DR: The ability of the instrument to obtain three dimensional images using the electron spin echo (ESE) and single point imaging (SPI) methods is demonstrated.
Journal ArticleDOI
Comparison of 250 MHz electron spin echo and continuous wave oxygen EPR imaging methods for in vivo applications
TL;DR: ESE is superior for hypoxia studies in tumors while missing voxels in high pO2 regions, and ESE and CW have different areas of applicability.
Journal ArticleDOI
In vivo preclinical cancer and tissue engineering applications of absolute oxygen imaging using pulse EPR
TL;DR: A summary review of the progress in biomedical EPR imaging, predominantly in cancer biology research, and discuss EPR oxygen imaging for cancer treatment and tissue graft assessment for regenerative medicine applications are provided.
Journal ArticleDOI
Simulation of 4D spectral-spatial EPR images.
Kang-Hyun Ahn,Howard J. Halpern +1 more
TL;DR: A simulation tool for EPRI was developed and various sampling schemes were tried to find an optimized parameter set under the customized noise model of this EPR imager, achieving the same performance as the experiment.
References
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Journal ArticleDOI
Survey: interpolation methods in medical image processing
TL;DR: The goal of this study was to present a comprehensive catalogue of methods in a uniform terminology, to define general properties and requirements of local techniques, and to enable the reader to select that method which is optimal for his specific application in medical imaging.
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Interpolation revisited [medical images application]
TL;DR: Based on the theory of approximation, this paper presents a unified analysis of interpolation and resampling techniques and shows that, contrary to the common belief, those that perform best are not interpolating.
Journal ArticleDOI
Imaging radio frequency electron‐spin‐resonance spectrometer with high resolution and sensitivity for in vivo measurements
Howard J. Halpern,David P. Spencer,Jerry van Polen,Michael K. Bowman,Alan C. Nelson,Elizabeth M. Dowey,Beverly A. Teicher +6 more
TL;DR: In this article, a radio frequency electron spin resonance spectrometer was proposed to provide high molar sensitivity and resolution in vivo for DPPH measurements with a modest sacrifice of sensitivity.
Journal ArticleDOI
Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): Methodology and comparison with blood oxygen level‐dependent (BOLD) MRI
Martyna Elas,Benjamin B. Williams,Adrian D. Parasca,Colin Mailer,Charles A. Pelizzari,Marta A. Lewis,Jonathan N. River,Gregory S. Karczmar,Eugene D. Barth,Howard J. Halpern +9 more
TL;DR: The potential for EPRI to display, at high spatial resolution, quantitative oxygen tension changes in the physiologic response to environmental changes is demonstrated.
Journal ArticleDOI
Linewidth analysis of spin labels in liquids. I. Theory and data analysis
TL;DR: A major advance in this method is the correction for the broadening produced by Zeeman modulation commonly used to obtain EPR signals; this allows experimenters much more freedom to optimize their experimental conditions for the best signal-to-noise ratio.