Journal ArticleDOI
Compritol 888 ATO: an innovative hot-melt coating agent for prolonged-release drug formulations.
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TLDR
The study confirms the satisfactory coating potential of the hot-melt fluid-bed coating process on large spherules or granules with Compritol 888, and several competing mechanisms are also involved, including a diffusion-controlled process and a dissolution mechanism.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 1999-01-01. It has received 118 citations till now. The article focuses on the topics: Hot melt coating & Coating.read more
Citations
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Journal ArticleDOI
Physical and thermal characterisation of Precirol and Compritol as lipophilic glycerides used for the preparation of controlled-release matrix pellets.
TL;DR: The evaluation of the thermal and rheological properties of Precirol and Compritol mixtures have shown that the use of such mixtures, presenting well distinct melting properties, could be a very interesting tool for the preparation of high fatty binder content prolonged-release pellets in high shear mixers if the product temperature is carefully controlled during the pelletisation process.
Journal ArticleDOI
Solventless pharmaceutical coating processes: a review.
Sagarika Bose,Robin H. Bogner +1 more
TL;DR: Six solventless coating methods—compression coating, hot-melt coating, supercritical fluid spray coating, electrostatic coating, dry powder coating, and photocurable coating—that can be used to coat the pharmaceutical dosage forms are discussed and compared.
Journal ArticleDOI
Compritol 888 ATO: a multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals
TL;DR: A review aimed at summarizing the current and potential applications of Compritol 888 ATO in various drug delivery areas and the number of articles that emphasize on its applicability as an innovative excipient in pharmaceutical technology is continuously increasing.
Journal ArticleDOI
Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms
TL;DR: This review aims to summarize all currently known aspects of controlled release systems containing solid dispersions, focusing on the preparation methods, mechanisms of action and characterization of physicochemical properties of the system.
Journal ArticleDOI
In vitro controlled release of sodium ferulate from Compritol 888 ATO-based matrix tablets.
TL;DR: The co-mixing of polyethylene glycol 6000 (PEG 6000) in the waxy matrices played a meaningful role in controlling the drug release for 24h, which might be attributed to the diffusion-controlled mechanism.
References
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BookDOI
Multiparticulate Oral Drug Delivery
TL;DR: Bodmeier et al. as discussed by the authors discussed the development of Modified-release Pellets Mechanisms of Release from Coated Pellets and the manufacturing of Multiparticulate Dosage Forms.
Controlled release: mechanisms and release.
Richard W. Baker,H.K. Lonsdale +1 more
TL;DR: In this paper, a control-release system of drug administration is discussed with an explanation of how the controlled release of agents according to zero-order of 1st-order kinetics arises from membrane-moderated devices and the application of diffusion laws.
Journal ArticleDOI
Characterization of a hot-melt fluid bed coating process for fine granules.
TL;DR: The equipment modifications and process changes necessary to perform hot-melt particle coating in a fluid bed granulator in a specific case is presented in which partially hydrogenated cottonseed oil is coated onto fine granules composed of a hydrophobic drug and sucrose.
Related Papers (5)
Controlled release of tramadol hydrochloride from matrices prepared using glyceryl behenate.
Aiman A. Obaidat,Rana M. Obaidat +1 more