Journal ArticleDOI
Conformational behaviour and E/Z isomerization of N-acyl and N-aroylhydrazones
TLDR
In this paper, the stereochemical behavior of N -acyl and N -aroylhydrazones of aromatic aldehydes, of pyruvates and of acetone, in polar and less polar solvents, has been studied by HPLC and by NMR techniques.About:
This article is published in Tetrahedron.The article was published on 1986-01-01. It has received 203 citations till now. The article focuses on the topics: Cis trans isomerization & Conformational isomerism.read more
Citations
More filters
Journal ArticleDOI
Cis-trans isomerization of organic molecules and biomolecules: implications and applications.
Christophe Dugave,Luc Demange +1 more
TL;DR: This review focuses on the part of the molecule containing two atoms attached together by a double bond with substituents W-Z which may be found as two isomeric molecules.
Journal ArticleDOI
1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities.
Umut Salgın-Gökşen,Nesrin Gökhan-Kelekçi,Özgür Göktaş,Yavuz Köysal,Ekrem Kiliç,Şamil Işık,Göknur Aktay,Meral Özalp +7 more
TL;DR: While most compounds were exhibiting high activity in the analgesic-anti-inflammatory field, most of them were found to be inactive against bacteria and fungi.
Journal ArticleDOI
Synthesis and characterization of a cobalamin-colchicine conjugate as a novel tumor-targeted cytotoxin.
TL;DR: Attachment of colchicine to cobalamin is expected to increase the therapeutic index of the drug by limiting the side effects caused by the current nonselective administration of tubulin-targeted chemotherapeutic drugs.
Journal ArticleDOI
Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives.
TL;DR: New 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-subStituted benzal)hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents and exhibited more potent analgesic activity than ASA.
Journal ArticleDOI
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Arthur Eugen Kümmerle,Martine Schmitt,Suzana V.S. Cardozo,Suzana V.S. Cardozo,Claire Lugnier,Pascal Villa,Alexandra Basilio Lopes,Nelilma C. Romeiro,Hélène Justiniano,Marco A. Martins,Carlos A. M. Fraga,Jean-Jacques Bourguignon,Eliezer J. Barreiro +12 more
TL;DR: A quinazoline derivative was designed as a conformationally constrained NAH analogue and showed similar in vitro pharmacological profile, compared with 8a, which fully confirmed the working hypothesis supporting this work.
References
More filters
Journal ArticleDOI
A convenient method for obtaining free energies of activation by the coalescence temperature of an unequal doublet
H. Shanan-Atidi,K. H. Bar-Eli +1 more
Journal ArticleDOI
Pyridine-2-carbaldehyde 2-hydroxybenzoylhydrazone as a selective reagent for the extraction and spectrophotometric determination of iron(II)
TL;DR: Pyridine-2-carbaldehyde 2-hydroxybenzoylhydrazone reacts with iron(II) to produce a green 2:1 complex (λmax. = 640 nm, Iµ= 3.64 × 103 l mol-1 cm-1 in aqueous ethanolic solution, and λmax.
Journal ArticleDOI
Aroylhydrazones as chelating agents: d10-metal complexes of pyridine-2-carbaldehyde salicyloylhydrazone and x-ray structure of the zinc derivative
TL;DR: In this article, the crystal structure of the zinc derivative has been determined from diffractometer data to R = 0.072 for 1086 independent reflections, with unit-cell dimensions a = 18.193(2), b = 24.532(6), c = 11.535(2) A,β = 103.71(1)° and Z = 8.26(1).
Journal Article
Conformational study on N-acylhydrazones of aromatic aldehydes by NMR spectroscopy.
Journal ArticleDOI
Determination of Uranium by Reversed-Phase High-Performance Liquid Chromatography
TL;DR: In this paper, a new chromatographic procedure is proposed; this procedure is based on the separation and determination of UO/sub 2/sup 2 +/ as a neutral complex, using reversed-phase chromatography and spectrophotometric detection.