Content and quality of 2000 controlled trials in schizophrenia over 50 years.
Ben Thornley,Clive E Adams +1 more
TLDR
The drug regulatory authorities should stipulate that the results of both explanatory and pragmatic trials are necessary before a compound is given a licence for everyday use, and much scope for well planned, conducted, and reported trials is left.Abstract:
Objective To provide a comprehensive survey of the content and quality of intervention studies relevant to the treatment of schizophrenia. Design Data were extracted from 2000 trials on the Cochrane Schizophrenia Group9s register. Main outcome measures Type and date of publication, country of origin, language, size of study, treatment setting, participant group, interventions, outcomes, and quality of study. Results Hospital based drug trials undertaken in the United States were dominant in the sample (54%). Generally, studies were short (54% Conclusions Half a century of studies of limited quality, duration, and clinical utility leave much scope for well planned, conducted, and reported trials. The drug regulatory authorities should stipulate that the results of both explanatory and pragmatic trials are necessary before a compound is given a licence for everyday use.read more
Citations
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CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials
David Moher,Sally Hopewell,Kenneth F. Schulz,Victor M. Montori,Peter C Gøtzsche,Philip J. Devereaux,Diana Elbourne,Matthias Egger,Douglas G. Altman +8 more
TL;DR: This update of the CONSORT statement improves the wording and clarity of the previous checklist and incorporates recommendations related to topics that have only recently received recognition, such as selective outcome reporting bias.
Journal ArticleDOI
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
TL;DR: The revised CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.
Journal ArticleDOI
The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
Douglas G. Altman,Kenneth F. Schulz,David Moher,Matthias Egger,Frank Davidoff,Diana Elbourne,Peter C Gøtzsche,Tom Lang +7 more
TL;DR: The Consort Statement as mentioned in this paper is a group of scientists and editors developed to improve the quality of reporting of randomized, controlled trials (RCTs) by providing guidance to authors about how to improve their reporting of their trials.
Journal ArticleDOI
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials.
TL;DR: The revised CONSORT statement as discussed by the authors is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results, which can be achieved only through complete transparency from authors.
Journal ArticleDOI
The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials
TL;DR: The revised CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.
References
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?
Alejandro R. Jadad,R. A. Moore,Dawn Carroll,C. Jenkinson,David Reynolds,David J. Gavaghan,Henry J McQuay +6 more
TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Improving the quality of reporting of randomized controlled trials. The CONSORT statement.
Colin B. Begg,Mildred K. Cho,Susan Eastwood,Richard Horton,David Moher,Ingram Olkin,Roy M. Pitkin,Drummond Rennie,Kenneth F. Schulz,David L. Simel,Donna F. Stroup +10 more
TL;DR: For RCTs to ultimately benefit patients, the published report should be of the highest possible standard and should provide the reader with the ability to make informed judgments regarding the internal and external validity of the trial.
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Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses
David Moher,David Moher,Ba' Pham,Alison Jones,Deborah J. Cook,Alejandro R. Jadad,Michael Moher,Peter Tugwell,Terry P. Klassen,Terry P. Klassen +9 more
TL;DR: Study of low methodological quality in which the estimate of quality is incorporated into the meta-analyses can alter the interpretation of the benefit of intervention, whether a scale or component approach is used in the assessment of trial quality.
Journal ArticleDOI
Bias in Treatment Assignment in Controlled Clinical Trials
TL;DR: Differences in case-fatality rates between treatment and control groups were found, and the importance of keeping those who recruit patients for clinical trials from suspecting which treatment will be assigned to the patient under consideration is emphasized.
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What are pragmatic trials
Martin Roland,David J. Torgerson +1 more
TL;DR: The design of a pragmatic trial reflects variations between patients that occur in real clinical practice and aims to inform choices between treatments.