Open Access
Context-dependency of the relation between left ventricular mass and AGT gene variants
Tatiana Kuznetsova,J.A. Staessen,T Reineke,Agnieszka Olszanecka,A Ryabikov,Tikhonoff,Edoardo Casiglia,Robert Fagard,Kalina Kawecka-Jaszcz,Eva Brand +9 more
Reads0
Chats0
TLDR
A positive association between LVMI and the AGT −532T allele due to increased MWT was observed in Slavic male offspring and appeared to be modulated by the trophic effects of salt intake on LVM.About:
The article was published on 2004-06-01 and is currently open access. It has received 12 citations till now. The article focuses on the topics: Context (language use).read more
Citations
More filters
Journal ArticleDOI
Arterial stiffness, central hemodynamics, and cardiovascular risk in hypertension.
Paolo Palatini,Edoardo Casiglia,Jerzy Gąsowski,Jerzy Głuszek,Piotr Jankowski,Krzysztof Narkiewicz,Francesca Saladini,Katarzyna Stolarz-Skrzypek,Valérie Tikhonoff,Lucas Van Bortel,Wiktoria Wojciechowska,Kalina Kawecka-Jaszcz +11 more
TL;DR: This review summarizes several scientific contributions at the recent Satellite Symposium of the European Society of Hypertension, held in Milan, Italy, which suggested closer correlation of end-organ damage with central BP than with peripheral BP, and central BP may provide additional prognostic information regarding cardiovascular risk.
Journal ArticleDOI
Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy.
Wolfgang Lieb,Jochen Graf,Anika Götz,Inke R. König,Björn Mayer,Marcus Fischer,Jan Stritzke,Christian Hengstenberg,Stephan R. Holmer,Angela Döring,Hannelore Löwel,Heribert Schunkert,Jeanette Erdmann +12 more
TL;DR: Evidence is provided that genetic variants in the ACE2 gene may be associated withleft ventricular mass, SWT and left ventricular hypertrophy in hemizygous men and women and with blood pressure levels.
Journal ArticleDOI
Towards understanding the aetiology and pathophysiology of human hypertension: where are we now?
P Kakar,Gregory Y.H. Lip +1 more
TL;DR: Towards understanding the aetiology and pathophysiology of human hypertension: where are the authors now?
Journal ArticleDOI
Heritability of left ventricular structure and function in Caucasian families
Yu Jin,Tatiana Kuznetsova,Murielle Bochud,Tom Richart,Tom Richart,Lutgarde Thijs,Daniele Cusi,Robert Fagard,Jan A. Staessen,Jan A. Staessen +9 more
TL;DR: The study demonstrated moderate heritability for LV mass as well as the mitral annular Ea and Aa peaks, which support the ongoing research to map and detect genetic variants that contribute to the variation in LV mass and other LV structural and functional phenotypes.
Journal ArticleDOI
Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: the HyperGEN study
TL;DR: It is suggested that renin–angiotensin system variants in at least two genes may interact to modulate LVM, and ACE-by-AGT epistatic effects among hypertensive participants in the Hypertension Genetic Epidemiology Network study indicate this.
References
More filters
Journal ArticleDOI
Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.
TL;DR: The survey shows significant interobserver and interlaboratory variation in measurement when examining the same echoes and indicates a need for ongoing education, quality control and standardization of measurement criteria.
Journal ArticleDOI
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Richard B. Devereux,Richard B. Devereux,Daniel R. Alonso,Daniel R. Alonso,Elizabeth M. Lutas,Elizabeth M. Lutas,Geoffrey J. Gottlieb,Geoffrey J. Gottlieb,E Campo,E Campo,Irene Sachs,Irene Sachs,Nathaniel Reichek,Nathaniel Reichek +13 more
TL;DR: To determine the accuracy of echocardiographic left ventricular (LV) dimension and mass measurements for detection and quantification of LV hypertrophy, results of blindly read antemortem e chocardiograms were compared with LV mass measurements made at necropsy in 55 patients.
Journal ArticleDOI
A general test of association for quantitative traits in nuclear families.
TL;DR: A general approach that can accommodate nuclear families of any size, with or without parental information, is constructed, and it is shown that, when siblings are available, the total number of genotypes required in order to achieve comparable power is smaller if parents are not genotyped.
Journal ArticleDOI
Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. The Framingham Heart Study.
Daniel Levy,Keaven M. Anderson,Daniel D. Savage,William B. Kannel,Jane C. Christiansen,William P. Castelli +5 more
TL;DR: It is concluded that left ventricular hypertrophy is a common echocardiographic finding for which several risk factors can be identified and support weight reduction and blood pressure control for prevention or regression of this condition.
Journal ArticleDOI
Balancing life-style and genomics research for disease prevention
TL;DR: A balanced approach to genetic research for disease prevention should provide the best data to make informed choices about the most effective means to prevent disease.