Journal ArticleDOI
Contribution of B-1 Cells to Intestinal IgA Production in the Mouse
Frans G. M. Kroese,John J. Cebra,Maarten J. F. van der Cammen,Aaron B. Kantor,Nicolaas A. Bos +4 more
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TLDR
The data presented here show that, in principle, B-1 cells located in the peritoneal cavity may be an important source of precursors for intestinal IgA plasma cells in the mouse.About:
This article is published in Methods.The article was published on 1995-08-01. It has received 22 citations till now. The article focuses on the topics: CD40 & Adoptive cell transfer.read more
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Journal ArticleDOI
Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1
TL;DR: The sequestration function of D cyclins appears essential for Myc‐induced cell cycle progression but dispensable for apoptosis.
Journal Article
Biological Impact of Natural COOH-Terminal Deletions of Hepatitis B Virus X Protein in Hepatocellular Carcinoma Tissues
Hong Tu,Celestino Bonura,Carlo Giannini,Helene Mouly,Patrick Soussan,Michael C. Kew,Patrizia Paterlini-Bréchot,Christian Bréchot,Dina Kremsdorf +8 more
TL;DR: This study further supports the hypothesis that natural HBx mutants might be selected in tumor tissues and play a role in hepatocarcinogenesis by modifying the biological functions of HBx.
Journal ArticleDOI
The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis
TL;DR: It is demonstrated that the ATM-related domain of TRRAP forms a structural core for the assembly and recruitment of HAT complexes by transcriptional activators.
Journal ArticleDOI
B1 cells contribute to serum IgM, but not to intestinal IgA, production in gnotobiotic Ig allotype chimeric mice
TL;DR: Data suggest that intestinal IgA production induced by commensal bacteria is mainly performed by B2, not B1, cells, which might play a similar role in mucosal immunity.
Journal ArticleDOI
Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria.
Nicolaas A. Bos,Judy C. A. M. Bun,S. H. Popma,Ethel R. Cebra,Gerrit Jan Deenen,M. J. F. Van Der Cammen,Franciscus Kroese,John J. Cebra +7 more
TL;DR: Six to eight months after injection, only cells with the B1 phenotype were retained in the spleens and peritoneal cavities of these mice, and all the hybridomas reacted with different but partially overlapping fecal bacterial populations.
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Expansion and functional activity of Ly‐1+ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice
Irmgard Förster,Klaus Rajewsky +1 more