Journal ArticleDOI
Contribution of in vivo models of thrombosis to the discovery and development of novel antithrombotic agents.
TLDR
Animal models will play a primary role in the discovery and characterization of the novel antithrombotic agents that will provide safe and effective pharmacological treatment for life-threatening thrombosis diseases.About:
This article is published in Journal of Pharmacological and Toxicological Methods.The article was published on 2000-03-01. It has received 98 citations till now. The article focuses on the topics: Discovery and development of direct thrombin inhibitors & Antithrombotic.read more
Citations
More filters
Journal ArticleDOI
Critical Review of Mouse Models of Venous Thrombosis
Jose A. Diaz,Andrea T. Obi,Daniel D. Myers,Daniel D. Myers,Shirley K. Wrobleski,Peter K. Henke,Nigel Mackman,Thomas W. Wakefield +7 more
TL;DR: This work reviews the ferric chloride model, the inferior vena cava ligation model,The inferior v Rena cava stenosis models, and the electrolytic inferior venna cava model and compares their advantages and disadvantages.
Journal ArticleDOI
An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research
Xinkang Wang,Lin Xu +1 more
TL;DR: This study provides a simple, sensitive and highly controlled method for limiting vessel injury in mice to better detect the efficacy of antithrombotic drugs and/or evaluate therapeutic targets.
Journal ArticleDOI
Neuroprotection and stroke: time for a compromise.
TL;DR: This mini‐review will try to point out some of the weaknesses that could underline the failure of both researchers and clinicians involved in the field of stroke to obtain their ultimate goal – brain protection.
Journal ArticleDOI
Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory.
TL;DR: Findings in this review not only demonstrate a role for plasticity in learning, they also lay down the foundations for the new field of molecular and cellular cognition.
Journal ArticleDOI
Influence of virgin coconut oil on blood coagulation factors, lipid levels and LDL oxidation in cholesterol fed Sprague–Dawley rats
K.G. Nevin,T. Rajamohan +1 more
TL;DR: Results indicate that VCO feeding can prevent the oxidation of LDL from oxidants and may be attributed to the presence of biologically active unsaponifiable components viz .
References
More filters
Journal ArticleDOI
Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty.
TL;DR: Ischemic complications of coronary angioplasty and atherectomy were reduced with a monoclonal antibody directed against the platelet IIb/IIIa glycoprotein receptor, although the risk of bleeding was increased.
Journal ArticleDOI
A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group.
Marc Cohen,Christine Demers,Enrique P. Gurfinkel,A.G.G Turpie,Gregg J Fromell,Shaun G Goodman,Anatoly Langer,Robert M. Califf,Keith A.A. Fox,J. Premmereur,Frederique Bigonzi +10 more
TL;DR: Antithrombotic therapy with enoxaparin plus aspirin was more effective than unfractionated heparin plus aspirin in reducing the incidence of ischemic events in patients with unstable angina or non-Q-wave myocardial infarction in the early phase.
Journal ArticleDOI
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
TL;DR: In addition to metabolic differences, the anatomical, physiological, and biochemical differences in the gastrointestinal (G.I.) tract of the human and common laboratory animals can cause significant variation in drug absorption from the oral route.
Review article comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
TL;DR: In this article, anatomical, physiological, and biochemical differences in the gastrointestinal tract of the human and common laboratory animals can cause significant variation in drug absorption from the oral route, including metabolic differences.
Journal ArticleDOI
Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
Mark A. Kay,Catherine S. Manno,Catherine S. Manno,Margaret V. Ragni,Peter J. Larson,Peter J. Larson,Linda B. Couto,Alan McClelland,Bertil Glader,Amy J. Chew,Shing J Tai,Roland W. Herzog,Valder R. Arruda,Fred Johnson,Ciaran Scallan,Erik D. Skarsgard,Alan W. Flake,Alan W. Flake,Katherine A. High,Katherine A. High +19 more
TL;DR: Evidence of gene expression at low doses of vector suggests that dose calculations based on animal data may have overestimated the amount of vector required to achieve therapeutic levels in humans, and that the approach offers the possibility of converting severe haemophilia B to a milder form of the disease.
Related Papers (5)
Rat model of arterial thrombosis induced by ferric chloride
Formation of uniform spherical magnetite particles by crystallization from ferrous hydroxide gels
Tadao Sugimoto,Egon Matijević +1 more