Journal ArticleDOI
Conversion of testosterone into 5α-reduced metabolites in the anterior pituitary and in the brain of maturing rats
TLDR
The anterior pituitary of normal female rats shows a considerable 5α-reductase activity, which is much higher than that of male animals on day 14 of life, and this activity becomes very similar to that of normal males of the same age.About:
This article is published in Journal of Steroid Biochemistry.The article was published on 1975-05-01. It has received 55 citations till now. The article focuses on the topics: Anterior pituitary & Pituitary gland.read more
Citations
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Journal ArticleDOI
A review of brain aromatase cytochrome P450
TL;DR: It is clear that molecular mechanism(s) account for the diverse expression of aromatase in different neural tissue sites and during various physiological states or developmental periods and further study is necessary in order to understand the significance of the regulation of local estrogen biosynthesis by the arom atase cytochrome P450 gene during prenatal and postnatal development.
Journal ArticleDOI
Neurosteroid metabolism in the human brain.
TL;DR: Better knowledge of the biochemical pathways of neurosteroidogenesis and their actions on the brain seems to open new perspectives in the understanding of the physiology of the human brain as well as in the pharmacological treatment of its disturbances.
Journal ArticleDOI
Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides.
Jean Luc Do Rego,Jean Luc Do Rego,Jae Young Seong,Delphine Burel,Delphine Burel,Jérôme Leprince,Jérôme Leprince,Van Luu-The,Kazuyoshi Tsutsui,Marie Christine Tonon,Marie Christine Tonon,Georges Pelletier,Hubert Vaudry +12 more
TL;DR: The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.
Journal ArticleDOI
Hypothalamic‐pituitary‐gonadal relationships in man from birth to puberty
TL;DR: It is believed that the study of gonadal function of the child should be regarded as a whole, beginning with the fetus and ending with the adolescent, with 4 main phases of development: fetal, perinatal, prepubertal, and pubertal.
Book ChapterDOI
Androgen metabolism in the brain: behavioural correlates.
John B. Hutchison,Th. Steimer +1 more
TL;DR: Steroid metabolizing enzymes in the male brain provide a degree of plasticity in the action of hormones on brain mechanisms of behavior, and this chapter discusses the pathways of androgen metabolism in the brain relevant to behavior.
References
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Journal ArticleDOI
The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro.
TL;DR: It has been shown that in the presence of a NADPH2-generating system prostatic nuclei convert testosterone to dihydrotestosterone, whereas prostatic cytoplasm reduces dihydotestosterone to androstandiol.
Journal ArticleDOI
Comparison of the regulation of luteinizing hormone (LH) secretion in immature and adult rats.
Domingo V. Ramirez,S. M. McCann +1 more
TL;DR: Two to 3 weeks following gonadectomy, pituitary LH content had risen significantly in both adult females and immature males, whereas it remained unchanged in immature females and adult males, while plasma LH activity increased significantly in all gonadectomized groups.
Book ChapterDOI
The intranuclear metabolism of testosterone in the accessory organs of reproduction.
Jean D. Wilson,Robert E. Gloyna +1 more
TL;DR: This chapter discusses the intranuclear metabolism of testosterone in the accessory organs of reproduction, and it is tempting to speculate that dihydrotestosterone formation may have some special relation to the growth-promoting effects of testosterone.
Journal ArticleDOI
Metabolism of testosterone and action of metabolites on prostate glands grown in organ culture.
TL;DR: Preliminary experiments indicate that prostatic tissue grown in vitro metabolizes the hormone testosterone, and the action of testosterone could be caused directly by the hormone, or indirectly through its transformation into metabolites, for example, through tran-hydrogenation.
Journal ArticleDOI
Testosterone metabolism in target tissues. Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis.
TL;DR: Rat pituitary, hypothalamic and cerebral cortical minces are demonstrated to effect the conversion of testosterone (T) to 5α-androstan-17β-o1-3-one (DHT) and Δ4-androstene-3,17-dione (Δ4A).