Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development.
Florence Schaffner,Henri H. Versteeg,Henri H. Versteeg,Anja Schillert,Naho Yokota,Lars Christian Petersen,Barbara M. Mueller,Wolfram Ruf +7 more
TLDR
A crosstalk of tumor cell TF cytoplasmic domain and PAR2 signaling is demonstrated and provided a possible mechanism for the close correlation between TF phosphorylation and cancer recurrence of TF andPAR2-positive clinical breast cancer.About:
This article is published in Blood.The article was published on 2010-12-23 and is currently open access. It has received 99 citations till now. The article focuses on the topics: Cancer & Cell signaling.read more
Citations
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Inflammation, obesity, and thrombosis
Fahumiya Samad,Wolfram Ruf +1 more
TL;DR: In obese patients, clinical markers of a prothrombotic state may indicate a risk for the development of complications of the metabolic syndrome, and TF-induced signaling could provide new therapeutic targets for drug development at the intersection between obesity, inflammation, and thrombosis.
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The relationship between tissue factor and cancer progression: insights from bench and bedside
TL;DR: Evidence exists that TF-dependent signal transduction events are a potential target for therapeutic intervention in selected types of cancer, and speculation on anticancer therapy by targeting TF is speculated.
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Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice
Ana M. Gil-Bernabé,Špela Ferjančič,M. Tlalka,Lei Zhao,Philip D. Allen,Jae Hong Im,Karla Watson,Sally A. Hill,Ali Amirkhosravi,John L. Francis,Jeffrey W. Pollard,Wolfram Ruf,Ruth J. Muschel +12 more
TL;DR: It is shown that clot formation by TF indirectly enhances tumor cell survival after arrest in the lung, during experimental lung metastasis, by recruiting macrophages characterized by CD11b, CD68, F4/80, and CX(3)CR1 (but not CD11c) expression.
Journal ArticleDOI
Protease-activated receptor 2 signaling in inflammation
Andrea S. Rothmeier,Wolfram Ruf +1 more
TL;DR: The roles of PAR2 are reviewed with an emphasis on the role of coagulation and other extracellular protease pathways that cleave PAR2 in epithelial, immune, and neuronal cells to regulate physiological and pathophysiological processes.
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Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling
Christoph Reinhardt,Mattias Bergentall,Thomas U. Greiner,Florence Schaffner,Gunnel Östergren-Lundén,Lars Christian Petersen,Wolfram Ruf,Fredrik Bäckhed,Fredrik Bäckhed +8 more
TL;DR: It is shown that the gut microbiota promotes TF glycosylation associated with localization of TF on the cell surface, the activation of coagulation proteases, and phosphorylation of the TF cytoplasmic domain in the small intestine.
References
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Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.
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Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases
Elaine Y. Lin,Joan G. Jones,Ping Li,Liyin Zhu,Kathleen Whitney,William J. Muller,Jeffrey W. Pollard +6 more
TL;DR: The PyMT mouse model is demonstrated to be an excellent one to understand the biology of tumor progression in humans, and its comparison to human breast tumors is compared.
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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.
TL;DR: It is reported that agonists of Gαq-coupled proteinase–activated receptor 2 (PAR2) stimulate formation of a multiprotein signaling complex, as detected by gel filtration, immunoprecipitation and immunofluorescence, which might ensure appropriate subcellular localization of PAR2-mediated ERK activity, and determine the mitogenic potential of receptor agonists.
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Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype
TL;DR: Evidence is presented to support the hypothesis that thrombin serves to preserve dormant tumor cells in individuals, preventing host eradication and it is proposed that tumor malignancy may be regulated by a procoagulant/anticoagulants axis.
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Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor
Juan Carlos Rodríguez-Manzaneque,Timothy F. Lane,Maria Asuncion Ortega,Richard O. Hynes,Jack Lawler,M. Luisa Iruela-Arispe +5 more
TL;DR: The results argue for a protective role of endogenous inhibitors of angiogenesis in tumor growth and implicate TSP1 in the in vivo regulation of metalloproteinase-9 activation and VEGF signaling.