Journal ArticleDOI
Corneal cytotoxicity of topically applied drugs, vehicles and preservatives
TLDR
Corneal research techniques are reviewed, including scanning and transmission electron microscopy, electrophysiological techniques, and specular microscope observation, and clinical interpretation of these results is discussed.About:
This article is published in Survey of Ophthalmology.The article was published on 1980-07-01. It has received 201 citations till now.read more
Citations
More filters
Journal ArticleDOI
Management and therapy of dry eye disease: Report of the management and therapy subcommittee of the international Dry Eye WorkShop (2007)
Stephen C. Pflugfelder,Gerd Geerling,Shigero Kinoshita,Michael A. Lemp,James P. McCulley,Daniel Nelson,Gary N. Novack,Jun Shimazaki,Clive G. Wilson +8 more
TL;DR: The recommendations of the Management and Therapy Subcommittee are based on a modification of the ITF severity grading scheme, and suggested treatments were chosen from a menu of therapies for which evidence of therapeutic effect had been presented.
Journal ArticleDOI
Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication.
TL;DR: Most of the adverse reactions induced by P glaucoma medication are reversible after removing preservatives, and symptoms and signs are less prevalent when PF drops are used.
Journal ArticleDOI
Corneal epithelial wound healing.
TL;DR: The corneal surface is, without question, the most specialised 123 mm2* of the body's surface and forms an integral part of the ocular surface with which it shares several anatomical and physiological attributes.
Journal ArticleDOI
The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction.
Gerd Geerling,Joseph Tauber,Christophe Baudouin,Eiki Goto,Yukihiro Matsumoto,Terrence P. O'Brien,Maurizio Rolando,Kazuo Tsubota,Kelly K. Nichols +8 more
TL;DR: The goals of the subcommittee were to review the current practice and published evidence of medical and surgical treatment options for meibomian gland dysfunction and to identify areas with conflicting, or lack of, evidence, observations, concepts, or even mechanisms where further research is required.
Journal ArticleDOI
The pathology of dry eye.
TL;DR: Whatever the initial causes of dry eye, chronic dryness of the ocular surface results in inflammatory reactions and gradual destruction of the lacrimal glands and conjunctival epithelium, as both the cause and consequence of cell damage.
References
More filters
Journal Article
Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes
Journal Article
The effects of ophthalmic drugs, vehicles, and preservatives on corneal epithelium: a scanning electron microscope study.
R R Pfister,N Burstein +1 more
TL;DR: These studies show that the cytotoxicity of topical ocular preparations can be tested in an in vivo model and evaluated by scanning electron microscopy.
Journal ArticleDOI
Effects of local anesthetics on cell morphology and membrane-associated cytoskeletal organization in BALB/3T3 cells.
TL;DR: The relationship of the findings on local anesthetic-induced changes in cellular cytoskeletal systems is discussed in relation to previous proposals on plasma membrane organization and control of cell surface receptor topography and mobility.
Journal Article
Preservative cytotoxic threshold for benzalkonium chloride and chlorhexidine digluconate in cat and rabbit corneas.
TL;DR: It is presumed that binding of these surface active agents occurs almost immediately and is unaffected by tear film dilution, and studies measuring permeability increase in the human eye after preservative use are required to allow clinical interpretation of the data presented here.
Related Papers (5)
The effects of ophthalmic drugs, vehicles, and preservatives on corneal epithelium: a scanning electron microscope study.
R R Pfister,N Burstein +1 more