Coronavirus-induced coagulopathy during the course of disease.
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TLDR
Coagulation alterations in COVID-19 patients are found indicating significant hypercoagulability, which is visible despite antithrombotic treatment, and peak around week 3–4 of the disease.Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
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The complicated relationships of heparin-induced thrombocytopenia and platelet factor 4 antibodies with COVID-19.
TL;DR: In this paper, the authors conclude that platelet factor 4/heparin antibodies can be observed in COVID-19-infected patients, and they may occur at higher incidence than in historical non-COVID-9infected cohorts.
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Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru
Marco H. Carcamo Garcia,Diego D. Garcia Choza,Brenda J. Salazar Linares,Monica M. Diaz,Monica M. Diaz +4 more
TL;DR: This cross-sectional study found that headaches, and smell and taste dysfunction are common among patients presenting with mild-to-moderate acute COVID-19 in Lima, Peru.
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Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study.
Himanshu Dandu,Geeta Yadav,Hardeep Singh Malhotra,Saurabh Kumar Pandey,Ruovinuo Sachu,Kinjalk Dubey +5 more
TL;DR: The clinical and laboratory features of severe COVID-19 infection overlap with those of hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory disorder often associated with several viral infections as discussed by the authors.
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Evidence showing lipotoxicity worsens outcomes in covid-19 patients and insights about the underlying mechanisms
Rodrigo Cartin-Ceba,Biswajit Khatua,Bara El-Kurdi,Shubha Sagar Trivedi,Sergiy Kostenko,Zaid Imam,Ryan Smith,Christine L.H. Snozek,Sarah Navina,Vijeta Sharma,Bryce McFayden,Filip Ionescu,Eugene Stolow,S. Keiser,Aziz Tejani,Allison Harrington,Phillip P Acosta,Saatchi Kuwelker,Juan Fernando Echavarría,Girish B. Nair,Adam Bataineh,Vijay P. Singh +21 more
TL;DR: In this paper , the authors compared three hospitalized patient cohorts and conducted mechanistic studies to determine if lipotoxicity worsens COVID-19 mortality, and found that patients requiring ICU transfer had higher serum albumin unbound linoleic acid (LA).
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
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Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Chaomin Wu,Xiaoyan Chen,Yanping Cai,Jia’an Xia,Xing Zhou,Sha Xu,Han-Ping Huang,Li Zhang,Xia Zhou,Chunling Du,Yuye Zhang,Juan Song,Sijiao Wang,Yencheng Chao,Zeyong Yang,Jie Xu,Xin Zhou,Dechang Chen,Weining Xiong,Lei Xu,Feng Zhou,Jinjun Jiang,Chunxue Bai,Zheng Junhua,Yuanlin Song +24 more
TL;DR: Although high fever was associated with the development of ARDS, it was also associated with better outcomes among patients with ARDS and treatment with methylprednisolone may be beneficial for patients who develop ARDS.
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Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
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Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.
TL;DR: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronvirus pneumonia (NCP) cases were a concern.