COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology.
TLDR
In this article, the authors have been appointed by the European Society of Endocrinology (ESE) to update with the current statement ESE members and the whole endocrine community on the emerging endocrine phenotype of COVID-19 and its implication for the prevention and management of the disease.Abstract:
COVID-19 has completely changed our daily clinical practice as well as our social relations. Many organs and biological systems are involved in SARS-Cov-2 infection, either due to direct virus-induced damage or to indirect effects that can have systemic consequences. Endocrine system is not only an exception but its involvement in COVID-19 is so relevant that an “endocrine phenotype” of COVID-19 has progressively acquired clinical relevance. We have been appointed by the European Society of Endocrinology (ESE) to update with the current statement ESE members and the whole endocrine community on the emerging endocrine phenotype of COVID-19 and its implication for the prevention and management of the disease. Diabetes has a major role in this phenotype since it is one of the most frequent comorbidities associated with severity and mortality of COVID-19. Careful management including treatment modifications may be required for protecting our patients rather with known diabetes from the most dangerous consequences of COVID-19 or hospitalized with COVID-19, but also in patients with SARS-CoV-2 induced newly onset diabetes. Obesity increases susceptibility to SARS-CoV-2 and the risk for COVID-19 adverse outcome. Adequate nutritional management needs to be granted to patients with obesity or undernourishment in order to limit their increased susceptibility and severity of COVID-19 infection. Lack of vitamin D, hypocalcemia and vertebral fractures have also emerged as frequent findings in the hospitalized COVID-19 population and may negatively impact on the outcome of such patients. Also, in patients with adrenal insufficiency prompt adaptation of glucocorticoid doses may be needed. Moreover, in this updated statement role of sex hormones as well as peculiar pituitary and thyroid aspects of COVID-19 have been included. Finally, in view of the mass vaccination, potential implications for endocrine patients should be considered.read more
Citations
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COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives
TL;DR: It is hypothesize that SARS-CoV-2 contributes to age-related perturbations in endothelial and adipose tissue, which are known to characterize the early aging process, which would explain the long-lasting symptoms of Sars-Cov-2 as the result of an accelerated aging process.
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Vitamin D levels associate with blood glucose and BMI in COVID-19 patients predicting disease severity.
Luigi di Filippo,Agnese Allora,Mauro Doga,Anna Maria Formenti,Massimo Locatelli,Patrizia Rovere Querini,Stefano Frara,Andrea Giustina +7 more
TL;DR: In this paper, the authors evaluated the relationship between VD levels and inflammatory response, BMI, blood glucose and disease severity in COVID-19 patients, and showed that VD deficiency might be a common pathophysiological mechanism involved in the detrimental effect of hyperglycemia and adiposity on disease severity.
Journal ArticleDOI
The emerging osteo-metabolic phenotype of COVID-19: clinical and pathophysiological aspects.
TL;DR: An emerging feature of COVID-19 is a clinically relevant osteo-metabolic phenotype characterized by widespread acute hypocalcaemia and chronic hypovitaminosis D with high prevalence of vertebral fractures as discussed by the authors.
Journal ArticleDOI
Hypocalcemia in COVID-19 is associated with low vitamin D levels and impaired compensatory PTH response.
Luigi di Filippo,Agnese Allora,Massimo Locatelli,Patrizia Rovere Querini,Stefano Frara,Giuseppe Banfi,Andrea Giustina +6 more
TL;DR: In this paper, the role of hypovitaminosis D and parathyroid hormone (PTH) levels in the development of hypocalcemia in COVID-19 patients was investigated.
Journal ArticleDOI
COVID-19 and the Endocrine System: A Review of the Current Information and Misinformation
Samir A Mirza,Abdul Ahad Ehsan Sheikh,Michaela Barbera,Zainab Ijaz,Muhammad A. Javaid,Rahul Shekhar,S. Pal,Abu Baker Sheikh +7 more
TL;DR: This review highlights the basis of some pathophysiological mechanisms of COVID-19 infection-induced endocrine dysfunction and calls attention to the misinformation relating to CO VID-19 vaccination with supposed endocrine effects such as infertility and problems with pregnancy.
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