Journal ArticleDOI
Current anti-diabetic agents and their molecular targets: A review.
TLDR
This review offers a medium on which future drug design and development toward diabetes management may be modelled (i.e. optimization via structural derivatization), as many of the drug candidates highlighted show promise as an effective anti-diabetic chemotherapy.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2018-05-25. It has received 200 citations till now. The article focuses on the topics: Blood sugar & Diabetes mellitus.read more
Citations
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A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications.
Nagaraju Kerru,Lalitha Gummidi,Suresh Maddila,Kranthi Kumar Gangu,Sreekantha B. Jonnalagadda +4 more
TL;DR: This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
Journal ArticleDOI
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview.
Manoj Dhameja,Preeti Gupta +1 more
TL;DR: This review deals with recently discovered heterocyclic molecules that have been evaluated to exhibit inhibition of α-glucosidase enzyme in the treatment of type 2 diabetes mellitus.
Journal ArticleDOI
Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective
TL;DR: The naphthalene scaffold emerges as an important building block in drug discovery owing to its broad spectrum of biological activities through varying structural modifications.
Journal ArticleDOI
Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety.
Qiangqiang Jia,Ruyuan Zhu,Yimiao Tian,Beibei Chen,Rui Li,Lin Li,Lili Wang,Yiwen Che,Dandan Zhao,Fangfang Mo,Sihua Gao,Dongwei Zhang +11 more
TL;DR: SM may offer a new strategy for prevention and treatment of diabetes and its complications that stimulates extensive research into identifying potential anti-diabetic compounds and fractions as well as exploring the underlying mechanisms of this herb.
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Therapeutic significance of β-glucuronidase activity and its inhibitors: A review.
TL;DR: A compendium of exploits in the present millennium directed towards the inhibition of β GLU is presented, to proffer a platform on which new scaffolds can be modelled for improved βGLU inhibitory potency and the development of new therapeutic agents in consequential.
References
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Global estimates of diabetes prevalence for 2013 and projections for 2035.
TL;DR: The new estimates of diabetes in adults confirm the large burden of diabetes, especially in developing countries, particularly in low- and middle-income countries.
Journal ArticleDOI
The Mechanisms of Action of PPARs
Joel P. Berger,David E. Moller +1 more
TL;DR: The current state of knowledge regarding the molecular mechanisms of PPAR action and the involvement of the PPARs in the etiology and treatment of several chronic diseases is presented.
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New families in the classification of glycosyl hydrolases based on amino acid sequence similarities.
TL;DR: On the basis of a comparison of 482 sequences corresponding to 52 EC entries, 45 families, out of which 22 are polyspecific, can now be defined and has been implemented in the SWISS-PROT protein sequence data bank.
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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
Yasuaki Itoh,Yuji Kawamata,Masataka Harada,Makoto Kobayashi,Ryo Fujii,Shoji Fukusumi,Kazuhiro Ogi,Masaki Hosoya,Yasuhiro Tanaka,Hiroshi Uejima,Hideyuki Tanaka,Minoru Maruyama,Rie Satoh,Shoichi Okubo,Hideki Kizawa,Hidetoshi Komatsu,Fumika Matsumura,Yuko Noguchi,Tokuyuki Shinohara,Shuji Hinuma,Yukio Fujisawa,Masahiko Fujino +21 more
TL;DR: It is shown that a G-protein-coupled receptor, GPR40, which is abundantly expressed in the pancreas, functions as a receptor for long-chain FFAs, and that long- Chain FFAs amplify glucose-stimulated insulin secretion from pancreatic β cells by activating GPR 40.
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Oral antidiabetic agents: current role in type 2 diabetes mellitus.
TL;DR: Concern about cardiovascular safety of sulphonylureas has largely dissipated with generally reassuring results from clinical trials, including the UKPDS, and the insulin-sensitising thiazolidinedione class of antidiabetic agents has potentially advantageous effects on multiple components of the metabolic syndrome.