Journal ArticleDOI
Cutaneous innervation in impaired diabetic wound healing.
TLDR
In this paper, the authors provide an overview of wound healing pathophysiology with a focus on neural involvement in normal and diabetic wound healing, as well as future therapeutic perspectives to address the unmet needs of diabetic patients with chronic wounds.About:
This article is published in Translational Research.The article was published on 2021-10-01. It has received 24 citations till now. The article focuses on the topics: Diabetic foot ulcer & Wound healing.read more
Citations
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Journal ArticleDOI
Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine
Fang Huang,Xiangyu Lu,Yan Yang,Yushan Yang,Yongyong Li,Le Kuai,Bin Li,Haiqing Dong,Jianlin Shi +8 more
TL;DR: In this paper , a review summarizes the microenvironmental characteristics of diabetic foot ulcers, presents the main progress of wound healing, and summaries the state-of-the-art therapeutic strategies for DFU.
Journal ArticleDOI
Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers
Jiawei Feng,Jialin Wang,Yuqing Wang,Xiaoting Huang,Tengteng Shao,Xiaofei Deng,Ye-min Cao,M. Zhou,Cheng Zhao +8 more
TL;DR: Examination of the pathogenesis of diabetic ulcer wound healing reveals that oxidative stress and lipid peroxidation are common pathological mechanisms of ferroptosis and delayed wound healing in diabetic ulcers.
Journal ArticleDOI
Electrospun Chitosan–Polyvinyl Alcohol Nanofiber Dressings Loaded with Bioactive Ursolic Acid Promoting Diabetic Wound Healing
TL;DR: In this paper , ursolic acid (UA) extracted from Chinese herbal plants was encapsulated into electrospun nanofibers made from a blend of chitosan (CS) and polyvinyl alcohol (PVA) to generate innovative CS-PVA-UA dressings for diabetic wound treatment.
Journal ArticleDOI
Epigenetics: key to improve delayed wound healing in type 2 diabetes.
TL;DR: In this paper, the role of epigenetic mechanisms in controlling tissue repair, angiogenesis, and expression of growth factors, as well as recent findings that show the alteration of epigenetics events during diabetic wound healing.
Journal ArticleDOI
A Whole‐Course‐Repair System Based on Neurogenesis‐Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing
Yuan Xiong,Ze-biao Lin,Pengzhen Bu,Tao Yu,Yori Endo,Wu Zhou,Yun Sun,Faqi Cao,Guandong Dai,Yiqiang Hu,Li Lu,Liang Cheng,Peng Cheng,Kangkang Zha,Mohammad-Ali Shahbazi,Qian Feng,Bobin Mi,Guohui Liu +17 more
TL;DR: In this article , a whole-course-repair system is introduced by a hydrogel to concurrently achieve a mutually supportive cycle of neurogenesis-angiogenesis under a favorable immune microenvironment.
References
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Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
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Global and societal implications of the diabetes epidemic
TL;DR: The prevention of diabetes and control of its micro- and macrovascular complications will require an integrated, international approach if the authors are to see significant reduction in the huge premature morbidity and mortality it causes.
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IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040.
Katherine Ogurtsova,J. D. da Rocha Fernandes,Yadi Huang,Ute Linnenkamp,Leonor Guariguata,Nam H. Cho,Nam H. Cho,David Cavan,Jonathan E. Shaw,Lydia Makaroff,Lydia Makaroff +10 more
TL;DR: Diabetes prevalence, deaths attributable to diabetes, and health expenditure due to diabetes continue to rise across the globe with important social, financial and health system implications.
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Economic costs of diabetes in the US in 2002.
TL;DR: In this paper, the authors estimated the direct medical and indirect productivity-related costs attributable to diabetes and calculated and compared the total and per capita medical expenditures for people with and without diabetes.
Journal ArticleDOI
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
Goodarz Danaei,Mariel M. Finucane,Yuan Lu,Gitanjali M Singh,Melanie J. Cowan,Christopher J. Paciorek,Christopher J. Paciorek,John K Lin,Farshad Farzadfar,Young-Ho Khang,Gretchen A Stevens,Mayuree Rao,Mohammed K. Ali,Leanne M Riley,Carolyn Robinson,Majid Ezzati +15 more
TL;DR: Glycaemia and diabetes are rising globally, driven both by population growth and ageing and by increasing age-specific prevalences, and effective preventive interventions are needed, and health systems should prepare to detect and manage diabetes and its sequelae.
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