Journal ArticleDOI
Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction.
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TLDR
A statistically significant reduction in the amount of autonomic nerve supplying detrusor muscle was demonstrated in the obstructed group, providing additional evidence that functional impairment of the urinary bladder occurs in response to outflow obstruction and emphasizes the need for prompt relief of the condition.About:
This article is published in The Journal of Urology.The article was published on 1986-08-01. It has received 205 citations till now. The article focuses on the topics: Detrusor muscle & Urinary bladder.read more
Citations
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Journal ArticleDOI
Urinary bladder contraction and relaxation: Physiology and pathophysiology
Karl-Erik Andersson,Anders Arner +1 more
TL;DR: The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors.
Journal ArticleDOI
A myogenic basis for the overactive bladder
TL;DR: Evidence is summarized supporting the conclusion that the spontaneous rises in pressure that occur in the overactive bladder, particularly in detrusor instability (DI), regardless of etiology, are myogenic.
Journal ArticleDOI
Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence
Karl-Erik Andersson,Alan J. Wein +1 more
TL;DR: Antimuscarinics are the main-stay of pharmacological treatment of the overactive bladder syndrome, which is characterized by urgency, frequency, and urge incontinence.
Journal ArticleDOI
Bladder Outflow Obstruction—A Cause of Denervation Supersensitivity
TL;DR: Results suggest that agents capable of stabilising the bladder smooth muscle membrane may be useful in the treatment of detrusor instability secondary to bladder outflow obstruction.
Journal ArticleDOI
Detrusor Underactivity and the Underactive Bladder: A New Clinical Entity? A Review of Current Terminology, Definitions, Epidemiology, Aetiology, and Diagnosis
Nadir I. Osman,Christopher R. Chapple,Paul Abrams,Roger R. Dmochowski,François Haab,Victor W. Nitti,Heinz Koelbl,Philip Van Kerrebroeck,Alan J. Wein +8 more
TL;DR: To review the current terminology, definitions, and diagnostic criteria in use, along with the epidemiology and aetiology of DU, as a basis for building a consensus on the standardisation of current concepts, a review of the literature and the development of optimal management approaches is conducted.
References
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Journal ArticleDOI
Smooth Muscle Cell Hypertrophy and Hyperplasia in the Rat Detrusor after Short-Time Infravesical Outflow Obstruction
TL;DR: The previously reported decreased ability to pressure production at small volumes in the rat urinary bladder subjected to an acute infravesical outflow obstruction might thus, at least in part, be due to changed contractile properties of the hypertrophic cells, and/or to an inefficient incorporation of the newly formed smooth muscle cells.
Journal ArticleDOI
Morphological and morphometric studies of the human obstructed, trabeculated urinary bladder.
TL;DR: Comparison of the results obtained showed that smooth muscle cells undergo compensatory hypertrophy in response to outflow obstruction, which is a characteristic of those bladders which possess cells showing the largest increase in cell size.
Journal ArticleDOI
The effect of age on the autonomic innervation of the urinary bladder.
TL;DR: In this paper, a significant linear reduction in the amount of acetylcholinesterase-positive nerve was observed with increasing age, and axon profiles and measurement of smooth muscle cell cross-sectional areas in the electron microscope revealed a similar reduction in nerve per mm2 of detrusor muscle tissue.
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The effect of short-term obstruction on urinary bladder function in the rabbit.
TL;DR: The results of these studies demonstrate the rapid nature of the response of the bladder to chronic obstruction and highlight the importance of knowing the carrier and removal status of canine coronavirus.
Journal ArticleDOI
Structure of Trabeculated Detrusor Smooth Muscle in Cases of Prostatic Hypertrophy
John A. Gosling,John S. Dixon +1 more
TL;DR: The light and electron microscopic structure of biopsy samples of trabeculated urinary bladder from patients with proven outlfow obstruction due to prostic hypertrophy has been compared with the morphology of control bladder specimens to form a baseline for comparision with the results of future morphological studies oftrabeculation arising in response to different aetiological factors.
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Effect of bladder outlet obstruction on micturition reflex pathways in the rat.
W. D. Steers,William C. de Groat +1 more