Dehydration in Hospital-Admitted Stroke Patients Detection, Frequency, and Association
TLDR
Patients with dehydration were significantly more likely to be dead or dependent at hospital discharge than those without and further work is required to establish if these associations are causal and if preventing or treating dehydration improves outcomes.Abstract:
Background and Purpose—We aimed to determine the frequency of dehydration, risk factors, and associations with outcomes at hospital discharge after stroke. Methods—We linked clinical data from stroke patients in 2 prospective hospital registers with routine blood urea and creatinine results. Dehydration was defined by a blood urea-to-creatinine ratio >80. Results—Of 2591 patients registered, 1606 (62%) were dehydrated at some point during their admission. Independent risk factors for dehydration included older age, female gender, total anterior circulation syndrome, and prescribed diuretics (all P<0.001). Patients with dehydration were significantly more likely be dead or dependent at hospital discharge than those without (χ2=170.5; degrees of freedom=2; P<0.0001). Conclusions—Dehydration is common and associated with poor outcomes. Further work is required to establish if these associations are causal and if preventing or treating dehydration improves outcomes.read more
Citations
More filters
Journal ArticleDOI
Is This Elderly Patient Dehydrated? Diagnostic Accuracy of Hydration Assessment Using Physical Signs, Urine, and Saliva Markers
Matthew B. Fortes,Julian A. Owen,Philippa Raymond-Barker,Claire Bishop,Salah Elghenzai,Samuel J. Oliver,Neil P. Walsh +6 more
TL;DR: Saliva osmolality demonstrated superior diagnostic accuracy compared with physical signs and urine markers, and may have utility for the assessment of both water-loss and water-and-solute-loss dehydration in older individuals.
Journal ArticleDOI
The Role of the Cerebral Capillaries in Acute Ischemic Stroke: The Extended Penumbra Model:
Leif Østergaard,Leif Østergaard,Sune Nørhøj Jespersen,Kim Mouridsen,Irene Klærke Mikkelsen,Kristjana Ýr Jónsdóttir,Anna Tietze,Anna Tietze,Jakob Udby Blicher,Jakob Udby Blicher,Rasmus Aamand,Niels Hjort,Niels Hjort,Nina K. Iversen,Changsi Cai,Kristina D Hougaard,Kristina D Hougaard,Claus Z Simonsen,Claus Z Simonsen,Paul von Weitzel-Mudersbach,Boris Modrau,Kartheeban Nagenthiraja,Lars Riisgaard Ribe,M. Hansen,Susanne Lise Bekke,Martin Gervais Dahlman,Josep Puig,Salvador Pedraza,Joaquín Serena,T.-H. Cho,Susanne Siemonsen,Götz Thomalla,Jens Fiehler,Norbert Nighoghossian,Grethe Andersen +34 more
TL;DR: This work modeled the effects of progressive increases in CTTH on the way in which brain tissue can secure sufficient oxygen to meet its metabolic needs and predicted that as CTTH increases, CBF responses to functional activation and to vasodilators must be suppressed to maintain sufficient tissue oxygenation.
Journal ArticleDOI
Associations between the organisation of stroke services, process of care, and mortality in England: prospective cohort study
Benjamin Bray,Salma Ayis,Salma Ayis,James Campbell,Alex Hoffman,M. Roughton,Pippa J. Tyrrell,Charles D.A. Wolfe,Charles D.A. Wolfe,Anthony Rudd,Anthony Rudd +10 more
TL;DR: Patients admitted to stroke services with higher levels of organisation are more likely to receive high quality care as measured by audited process measures of acute stroke care, adjusting for patient characteristics and controlling for selection bias.
Journal ArticleDOI
Cerebral Small Vessel Disease and Renal Function: Systematic Review and Meta-Analysis
TL;DR: In individuals who had not had a stroke, having more SVD features on imaging was associated with a worse renal function, which remained significant after controlling for hypertension, but this finding does not exclude a powerful co-associate effect of age or vascular risk factor exposure.
Journal ArticleDOI
Management of Blood Pressure During and After Recanalization Therapy for Acute Ischemic Stroke.
TL;DR: Low blood pressure targets after attempted recanalization depend both on the degree of reperfusion achieved as well as the extent of infarction present, however prospective clinical trials addressing this issue are warranted.
References
More filters
Journal ArticleDOI
Predicting outcome after acute and subacute stroke: development and validation of new prognostic models.
TL;DR: New regression models to predict survival to 30 days after stroke and survival in a nondisabled state at 6 months were produced with the use of established guidelines on 530 patients from a stroke incidence study and performed well enough to be used for epidemiological purposes such as stratification in trials or correction for case mix.
Journal ArticleDOI
Influence of Raised Plasma Osmolality on Clinical Outcome After Acute Stroke
Ajay Bhalla,S Sankaralingam,Ruth Dundas,Ramasamyiyer Swaminathan,Charles D.A. Wolfe,Anthony Rudd +5 more
TL;DR: Raised plasma osmolality on admission is associated with stroke mortality, after correcting for case mix and trials are required to determine whether correcting dehydration after stroke improves outcome.
Journal ArticleDOI
Dehydration and venous thromboembolism after acute stroke
James Kelly,Beverley J. Hunt,Roger R. Lewis,Ramasamyiyer Swaminathan,Alan R. Moody,Paul T. Seed,Anthony Rudd +6 more
TL;DR: Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients, and the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke is evaluated.
Journal ArticleDOI
The effect of age, sex and other factors on blood chemistry in health.
TL;DR: Evidence is given to suggest that many of the changes occurring in women at about 50 years should be attributed to hormonal changes, and in all instances when the menopause has a significant influence there is a rise in the concentration of the constituent concerned.
Journal ArticleDOI
Risks of Diuretic Usage following Stroke
TL;DR: Diuretic usage was associated with a significant increase in peak blood urea nitrogen across the entire stroke study sample, and the highest odds ratio for developing a peak blood Urea nitrogen≥45 was 19.8 for patients taking a diuretic who had dysphagia plus modified barium swallow evidence of penetration-aspiration.
Related Papers (5)
Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more