Journal ArticleDOI
Delayed haematological complications of mustard gas.
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Haematopoiesis could be affected by mustard gas and various haematological indices of 57 of these victims compared with previous data 5 years ago are compared.Abstract:
Haematopoiesis could be affected by mustard gas We randomly selected 318 chemical victims exposed to mustard gas and compared their cell blood counts and peripheral blood smears (PBS) with those of 377 healthy men, and also various haematological indices of 57 of these victims compared with previous data 5 years ago The average number of red blood cells and haemoglobin of victims compared with the controls was not significantly different, but they were increased compared with data from 5 years ago White blood cell counts, neutrophils and lymphocytes did not show any clinically meaningful difference compared with the control group but 20 cases with atypical lymphocytes in their PBS have been found Change in lymphocyte shape may be related to committed stem cell involvement Further studies on bone marrow cells and cell markers are needed to document this hypothesis The mild increase in erythroid cells and haemoglobin concentration may be due to chronic obstructive pulmonary disorder and other respiratory diseases in these patientsread more
Citations
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Journal ArticleDOI
Medical aspects of sulphur mustard poisoning
Kai Kehe,Ladislaus Szinicz +1 more
TL;DR: Sulphur mustard is one of the major chemical warfare agents developed and used during World War I and the Iran-Iraq war and until now about 30,000 victims still suffer from late effects of the agent.
Journal ArticleDOI
Mustard gas toxicity: the acute and chronic pathological effects
TL;DR: In the majority of patients, the most clinically serious long‐term consequences of MG poisoning are on the respiratory system, but the effects on the skin and other systems also have a significant impact on quality of life.
Journal Article
Immunobiological consequences of sulfur mustard contamination.
Zuhair Mohammad Hassan,Massoumeh Ebtekar,Mostafa Ghanei,Mohammad Taghikhani,Mohammad Reza Noori Daloii,Tooba Ghazanfari +5 more
TL;DR: The long term complications of these patients indicate the need to develop effective preventive and therapeutic strategies in the clinic, based upon immunopotentiating intervention and therapy.
Journal ArticleDOI
Sulfur mustard and respiratory diseases.
Feng Ru Tang,Weng Keong Loke +1 more
TL;DR: Clinical and pathophysiological changes of respiratory system in victims exposed to HD in the last century are systemically reviewed, and clinicians and researchers are updated on the mechanism of HD-induced acute and chronic lung damages, and on the relevant drug targets for future development of antidotes for HD.
Journal ArticleDOI
Role of oxidative stress in sulfur mustard-induced pulmonary injury and antioxidant protection
TL;DR: The proposed cellular and molecular mechanisms of SM on pulmonary damage, the importance of oxidative stress and the mechanisms by which SM induces OS and antioxidants depletion are discussed along with research on antioxidant therapy as a suitable antidote.
References
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Journal ArticleDOI
The Diversity of the Effects of Sulfur Mustard Gas Inhalation on Respiratory System 10 Years After a Single, Heavy Exposure: Analysis of 197 Cases
Ali Emad,Gholam Reza Rezaian +1 more
TL;DR: Although the respiratory symptoms of an acute sulfur mustard gas inhalation are usually transient and nonspecific, it can lead to the development of a series of chronic destructive pulmonary sequelae in such cases.
Journal ArticleDOI
Mustard Gas Poisoning, Chronic Bronchitis, and Lung Cancer: An Investigation into the Possibility that Poisoning by Mustard Gas in the 1914-18 War might be a Factor in the Production of Neoplasia
R. A. M. Case,A. J. Lea +1 more
TL;DR: Boyland and Horning as discussed by the authors reported that the number of British cases treated for war gas poisoning was 160,970, and 80 per cent of these cases were due to mustard gas poisoning.
Journal ArticleDOI
Reproductive function in men following exposure to chemical warfare with sulphur mustard
TL;DR: This study demonstrates that the exposure to sulphur mustard results in very low androgen levels and hypo-responsiveness to GnRH in the first five weeks and normalization by the twelfth week after injury, however, side effects of mustard on sperm cells persist and may cause defective spermatogenesis years after exposure.
Journal ArticleDOI
Effect of Topically Applied Sulphur Mustard on Antioxidant Enzymes in Blood Cells and Body Tissues of Rats
TL;DR: It is concluded that sulphur mustard at a sublethal dose inhibited antioxidant enzyme activities in WBC and spleen, and antioxidant enzymes in lymphatic tissues may be used as suitable models for assessing mustard toxicity.
Journal ArticleDOI
Effect of sulfur exposure on protease activity in human peripheral blood lymphocytes.
TL;DR: Exposure of human peripheral blood lymphocytes from normal donors to these alkylating agents resulted in an increase in cell associated protease activity, which may contribute to the pathology or act as an indicator to predict methods of therapeutic intervention for sulfur mustard toxicity.
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