Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.
TLDR
The respiratory tract contains dendritic cells that are capable of functioning in antigen presentation and that may be important in pulmonary immune responses.Abstract:
In this study, we identified a population of dendritic cells (DC) that exists throughout human and mouse pulmonary tissues, including the trachea, bronchi, alveoli, and visceral pleura. In human tissue, these DC were shown to be positive for HLA-DR and T200 antigens. In the mouse, the DC expressed not only Ia and the T200 antigen, but also Fc-IgG and C3bi receptors. Unlike alveolar macrophages, the DC were negative for nonspecific esterase staining and shared ultrastructural similarities with the DC described by Steinman (1), and with Langerhans' cells, even though they did not contain Birbeck granules. We were able to demonstrate that mouse pulmonary DC function in antigen presentation, as observed with the other DC. Thus, the respiratory tract contains DC that are capable of functioning in antigen presentation and that may be important in pulmonary immune responses.read more
Citations
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Journal ArticleDOI
Basal cells as stem cells of the mouse trachea and human airway epithelium
Jason R. Rock,Mark W. Onaitis,Emma L. Rawlins,Yun Lu,Cheryl P. Clark,Yan Xue,Scott H. Randell,Brigid L.M. Hogan +7 more
TL;DR: The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 and cytokeratins 5, which generate differentiated cells during postnatal growth and in the adult during both steady state and epithelial repair.
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Immunoregulatory functions of surfactant proteins.
TL;DR: The structure and functions of the surfactant proteins SP-A and SP-D in regulating host immune defence and in modulating inflammatory responses are reviewed.
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Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling
TL;DR: It is argued that exploiting well-described model systems using both human airway epithelial cells and the pseudostratified epithelium of the genetically tractable mouse trachea will enable crucial discoveries regarding the pathogenesis of airway disease.
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Downregulation of the Antigen Presenting Cell Function(s) of Pulmonary Dendritic Cells In Vivo by Resident Alveolar Macrophages
TL;DR: It is suggested that (consistent with the in vitro data) the resident PAM population actively suppresses the APC function of lung DC in situ, and electron microscopic examination of normal lung fixed by intravascular perfusion in the inflated state revealed that the majority are preferentially localized in recesses at the alveolar septal junctions.
BookDOI
Gram-Positive Bacteria
Gianni Pozzi,Jeremy M. Wells +1 more
TL;DR: (nose, skin esp; vagina) 1. Direct Invasion of Organs a. pneumonia b. meningitis c. osteomyelitis (children) d. acute bacterial endocarditis e. septic arthritis f. skin infection g. UTI
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