Journal ArticleDOI
Depression during mania: clinical observations and theoretical implications.
Joel Kotin,Frederick K. Goodwin +1 more
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TLDR
The relationship of depression to mania in 20 hospitalized patients was systematically investigated through an analysis of nurses' and physicians' behavioral ratings and notes, and statistically significant positive associations between mania and depression were found in the majority of cases.Abstract:
In the course of longitudinal studies of patients with manic-depressive illness, the authors regularly observed clear features of depression during periods of acute mania. The relationship of depression to mania in 20 hospitalized patients was systematically investigated through an analysis of nurses' and physicians' behavioral ratings and notes. Statistically significant positive associations between mania and depression were found in the majority of cases. The psychological implications of the concurrent presence of depression and mania are discussed.read more
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Journal ArticleDOI
Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders.
Hagop S. Akiskal,Marc Bourgeois,Jules Angst,Robert M. Post,Hans-Jürgen Möller,Robert M. A. Hirschfeld +5 more
TL;DR: The present review did not consider cyclic, seasonal, irritable-dysphoric or otherwise impulse-ridden, intermittently explosive or agitated psychiatric conditions for which the bipolar connection is less established.
Journal ArticleDOI
The dexamethasone suppression test for melancholia.
TL;DR: This review will focus on the most widely studied neuroendocrine disturbance: disinhibition of the hypothalamus-pituitary-adrenal cortex (HPA) system as revealed by the dexamethasone suppression test (DST).
Journal ArticleDOI
Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18.
Lewis R. Baxter,Michael E. Phelps,John C. Mazziotta,Jeffrey M. Schwartz,Robert H. Gerner,Carl Selin,Ron M. Sumida +6 more
TL;DR: The whole brain metabolic rates for patients with bipolar depression increased going from depression or a mixed state to a euthymic or manic state, and patients with unipolar depression showed a significantly lower ratio of the metabolic rate of the caudate nucleus, divided by that of the hemisphere as a whole.
Journal ArticleDOI
Outcome in Mania: A 4-Year Prospective Follow-up of 75 Patients Utilizing Survival Analysis
TL;DR: A 4-year follow-up of 75 patients was conducted to investigate outcome after recovery from an episode of mania, and predictors of an unfavorable outcome included poor occupational status prior to index episode, history of previous episodes, and history of alcoholism, psychotic features and symptoms during the index manic episode.