Journal ArticleDOI
Detection of Rhinovirus, Respiratory Syncytial Virus, and Coronavirus Infections in Acute Otitis Media by Reverse Transcriptase Polymerase Chain Reaction
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TLDR
These findings highlight the importance of common respiratory viruses, particularly HRV and RSV, in predisposing to and causing AOM in young children.Abstract:
Objective. To determine the frequencies of human rhinovirus (HRV), respiratory syncytial virus (RSV), and coronavirus (HCV) infection in children with acute otitis media (AOM). Methods. Middle ear fluids (MEF) collected by tympanocentesis and nasopharyngeal aspirates (NPA) at the time of the AOM diagnosis were examined by reverse transcriptase polymerase chain reaction for HRV, RSV, and HCV RNA. Patients. Ninety-two children aged 3 months to 7 years during a 1-year period. Results. Virus RNA was detected in a total of 69 children (75%) and in 44 MEF samples (48%) and 57 NPA samples (62%) at the time of AOM diagnosis. HRV RNA was detected in both MEF and NPA in 18 (20%), in MEF alone in 4 (4%), and in NPA alone in 10 (11%). RSV was detected in both MEF and NPA in 12 (13%), in MEF alone in 5 (5%), and in NPA alone in 9 (10%). HCV RNA was detected in both MEF and NPA in 5 (5%), in MEF alone in 2 (2%), and in NPA alone in 9 (10%). Dual viral infections were detected in 5% of children. HRV and RSV were detected simultaneously in 2 MEF samples and in 2 NPA samples; RSV and HCV were detected in 1 NPA sample. Bacterial pathogens were detected in 56 (62%) MEF from 91 children. Viral RNA was detected in 20 (57%) MEF of 35 bacteria-negative and in 25 (45%) of 56 bacteria-positive MEF samples. No important differences in the risk of treatment failure, relapse, or occurrence of late secretory otitis media were noted between children with virus-positive and virus-negative MEF aspirates. Conclusion. These findings highlight the importance of common respiratory viruses, particularly HRV and RSV, in predisposing to and causing AOM in young children.read more
Citations
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Journal ArticleDOI
The Diagnosis and Management of Acute Otitis Media
E. Tunkel,M. Rosenfeld,Xavier Sevilla,Richard H. Schwartz,Pauline A. Thomas,Mary Anne Jackson,Mark D. Joffe,Donald T. Miller,S. Lieberthal,Aaron E. Carroll,Theodore G. Ganiats +10 more
TL;DR: This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) andAmerican Academy of Family Physicians and provides recommendations to primary care clinicians for the management of children from 6 months through 12 years of age with uncomplicated AOM.
Journal ArticleDOI
The common cold
Terho Heikkinen,Asko Järvinen +1 more
TL;DR: Despite great advances in medicine, the common cold continues to be a great burden on society in terms of human suffering and economic losses and the role of rhinoviruses is most prominent.
Journal ArticleDOI
Prevalence of various respiratory viruses in the middle ear during acute otitis media
TL;DR: Respiratory syncytial virus is the principal virus invading the middle ear during acute otitis media in children and an effective vaccine against upper respiratory tract infections caused by respiratory syncyTial virus may reduce the incidence of acute OtitisMedia in children.
Journal ArticleDOI
Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic.
Babak Givi,Bradley A. Schiff,Steven B. Chinn,Daniel R. Clayburgh,N. Gopalakrishna Iyer,Scharukh Jalisi,Michael G. Moore,Cherie-Ann Nathan,Lisa A. Orloff,James P. O'Neill,Noah P. Parker,Chad A. Zender,Luc G. T. Morris,Louise Davies +13 more
TL;DR: In this paper, a set of safety recommendations was created based on a review of the literature and communications with physicians with firsthand knowledge of safety procedures during the COVID-19 pandemic.
Journal ArticleDOI
Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing.
Peter W. Heymann,Holliday T. Carper,Deborah D. Murphy,Thomas A.E. Platts-Mills,James T. Patrie,A.P. McLaughlin,Elizabeth A. Erwin,Marcus S Shaker,Martha A. Hellems,Jehanna Peerzada,Frederick G Hayden,Tina K. Hatley,Rachel Chamberlain +12 more
TL;DR: Evaluating the prevalence of viral respiratory tract pathogens among infants and children hospitalized for wheezing and analyzing the results in relation to the patient's age, atopic characteristics, and season of admission found respiratory syncytial virus was the dominant pathogen during the winter months, but rhinovirus was more common during other months.
References
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Journal ArticleDOI
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