Journal ArticleDOI
Determination of glomerular filtration rate in advanced renal insufficiency.
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TLDR
It is concluded that the precise measurement of low glomerular filtration rates requires the use of renal clearance techniques and four-hour 51Cr-EDTA renal clearance is a suitable method for measuring and following the development of renal function in advanced renal insufficiency.Abstract:
The glomerular filtration rate (GFR) has been determined in 17 patients with advanced renal insufficiency (GFR<15 ml/min) by different clearance techniques using creatinine, inulin and 51Cr-EDTA as filtration markers. With renal inulin clearance as reference method for GFR, endogenous renal creatinine clearance overestimated GFR by an average of 30%. Renal clearance of 51Cr-EDTA and inulin were closely correlated and thus 51Cr-EDTA is a suitable GFR marker even at low filtration rates. However, it was found that the plasma clearance of 51Cr-EDTA overestimated the GFR often by more than 100% in the range 2.6-11.2 ml/min. Renal clearance measured during 24 h was lower than 4 h renal clearance with the patient well hydrated and resting in bed. It is concluded that the precise measurement of low glomerular filtration rates requires the use of renal clearance techniques. Four-hour 51Cr-EDTA renal clearance is a suitable method for measuring and following the development of renal function in advanced renal insu...read more
Citations
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Journal ArticleDOI
Measuring GFR: a systematic review.
Inga Soveri,Ulla B. Berg,Jonas Björk,Carl-Gustaf Elinder,Anders Grubb,Ingegerd Mejàre,Gunnar Sterner,Sten-Erik Bäck +7 more
TL;DR: At least moderately strong evidence suggests that renal clearance of 51Cr-EDTA or iothalamate and plasma clearance of 50-labeled ethylenediaminetetraacetic acid or iohexol are sufficiently accurate methods to measure GFR.
Journal ArticleDOI
Report of the Radionuclides in Nephrourology Committee on Renal Clearance
M. D. Blaufox,Mattias Aurell,B. Bubeck,Enza Fommei,Amnon Piepsz,Charles D. Russell,Andrew Taylor,Henrik S. Thomsen,Duccio Volterrani +8 more
TL;DR: This report is meant to provide guidance to those centers that would like to initiate clearance procedures but have difficulty in choosing appropriate methodology.
Journal Article
Report of the radionuclides in nephrourology committee on renal clearance
M. D. Blaufox,Mattias Aurell,B. Bubeck,Enza Fommei,Amnon Piepsz,Charles D. Russell,Andrew Taylor,Henrik S. Thomsen,Duccio Volterrani +8 more
TL;DR: The need for simple and accurate methods to measure renal function is self-evident as mentioned in this paper, and this need increases as techniques for intervention become available, and the role of nuclear medicine in this area has been inhibited by confusion about conflicting methodologies.
Journal ArticleDOI
Validation of the modification of diet in renal disease formula for estimating GFR with special emphasis on calibration of the serum creatinine assay
TL;DR: The MDRD formula seems to be the best formula available for GFR estimating, but it is based on a serum creatinine method calibrated to give much lower values than most laboratories, leading to underestimation of GFR in mild renal insufficiency.
Journal ArticleDOI
Reference values for 51Cr-EDTA clearance as a measure of glomerular filtration rate.
Göran Granerus,Mattias Aurell +1 more
TL;DR: Reference values for glomerular filtration rate (GFR) were defined using eight reports including epidemiological studies and studies in kidney donors, with emphasis on the use of plasma clearance of 51Cr-EDTA estimated with single injection technique as the new reference method for GFR measurement.
References
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Journal ArticleDOI
A simple method for the determination of glomerular filtration rate
TL;DR: In 74 adult patients suffering from various renal diseases, the total [51Cr]EDTA plasma clearance (Cl) was compared to the [ 51Cr)EDTA clearance obtained on assuming a one-pool system (Cl1).
Journal Article
Glomerular filtration rate measurement in man by the single injection methods using 51Cr-EDTA.
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Renal inulin clearance versus total plasma clearance of 51Cr-EDTA.
TL;DR: The use of 51 Cr-EDTA clearance for deteermination of GFR is justisfied in view of the close correspondence between inulin clearance and plasma clearance of 51Cr- EDTA.
Journal ArticleDOI
MEASUREMENT OF GLOMERULAR FILTRATION-RATE IN MAN USING A 51Cr/EDETIC-ACID COMPLEX
TL;DR: Equilibration with interstitial fluid in non-œdematous patients takes less than 2 hours and there is no detectable extrarenal uptake so that the " slope " method based on 2-4-hour plasma-activity measurements can be used as a simple routine procedure.
Journal ArticleDOI
Glomerular Filtration Rate
TL;DR: The yield of different screening strategies aimed at identifying people with low glomerular filtration rates is described, and no trials to show whether the benefits of screening for low glomersular filTration rate outweigh the harms have been conducted.