Journal ArticleDOI
Determination of lipophilicity by means of reversed-phase thin-layer chromatography: I. Basic aspects and relationship between slope and intercept of TLC equations
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In this paper, the authors re-examine all the TLC equations in order to assess whether the relationship between intercepts and slopes is a basic feature of the chromatographic determination of lipophilicity.About:
This article is published in Journal of Chromatography A.The article was published on 1994-02-25. It has received 126 citations till now.read more
Citations
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Journal ArticleDOI
Separation methods for estimating octanol-water partition coefficients.
Salwa K. Poole,Colin F. Poole +1 more
TL;DR: The experimental determination of solute descriptors offers an alternative approach for estimating logP, and other biopartitioning properties, which is suitable for the rapid, high throughput determination of logP for neutral, weakly acidic, and weakly basic compounds.
Journal ArticleDOI
Alternative measures of lipophilicity: From octanol–water partitioning to IAM retention
TL;DR: This review describes lipophilicity parameters currently used in drug design and QSAR studies and focuses on Immobilised Artificial Membrane chromatography as an alternative which combines membrane simulation with rapid measurements.
Journal ArticleDOI
High-performance separations in the determination of triazine herbicides and their residues
TL;DR: The present state of analysis for triazine herbicides and their residues is critically surveyed in this paper, where the authors summarize the properties of triazines and the history of the determination of the parent compounds and their residue.
Journal ArticleDOI
Revisiting thin-layer chromatography as a lipophilicity determination tool--a comparative study on several techniques with a model solute set.
Łukasz Komsta,Robert Skibiński,Anna Berecka,Anna Gumieniczek,Beata Radkiewicz,Małgorzata Radoń +5 more
TL;DR: In this article, a comparative study on several approaches of TLC lipophilicity determination is presented, including a single TLC run, extrapolation of a retention matrix, principal component analysis (PCA), PARAFAC on a three-way array and a PLS regression.
Journal ArticleDOI
Synthesis, characterization and in vitro photodynamic antimicrobial activity of basic amino acid-porphyrin conjugates.
Meng Shuai,Zengping Xu,Ge Hong,Lihui Zhao,Zhanjuan Zhao,Guo Jianghong,Haiying Ji,Tianjun Liu +7 more
TL;DR: These basic amino acid-porphyrin conjugates are potential photosensitizers for PACT, and their syntheses, structural characterizations, oil-water partition coefficients, singlet oxygen generation yields, photo-stability, and photo inactivation efficacies are reported.
References
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Journal ArticleDOI
Partition coefficients and their uses
Journal ArticleDOI
Solvophobic interactions in liquid chromatography with nonpolar stationary phases
TL;DR: In this article, the solvophobic theory of solvent interaction with non-polar stationary phases in liquid chromatography is examined on the basis of solvophobia theory and a detailed analysis of the effect of the solvent on this process yields an expression for the capacity factor with essentially no adjustable constants.
Journal ArticleDOI
Gradient elution in high-performance liquid chromatography
L.R. Snyder,J.W. Dolan,J.R. Gant +2 more
TL;DR: In this article, a general theory of separation for gradient elution with reversed-phase systems is presented, and expressions for retention, resolution, band width and other separation parameters are presented as a function of experimental variables.
Journal ArticleDOI
Influence of organic modifiers on the rentention behaviour in reversed-phase liquid chromatography and its consequences for gradient elution
TL;DR: In this paper, an extensive study of 32 aromatic compounds in aqueous system containing 10-100% of methanol, acetonitrile and tetrahydro-furan as organic modifiers under isocratic conditions is described.
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