scispace - formally typeset
Journal ArticleDOI

Developing artificial hydrolytic metalloenzymes by a unified mechanistic approach

Jik Chin
- 01 May 1991 - 
- Vol. 24, Iss: 5, pp 145-152
About: 
This article is published in Accounts of Chemical Research.The article was published on 1991-05-01. It has received 434 citations till now.

read more

Citations
More filters
Journal ArticleDOI

Oxidative Nucleobase Modifications Leading to Strand Scission

Cynthia J. Burrows, +1 more
- 01 Apr 1998 - 
Journal ArticleDOI

Synthetic analogues relevant to the structure and function of zinc enzymes.

Gerard Parkin
- 24 Jan 2004 - 
Journal ArticleDOI

Additions to Metal-Activated Organonitriles†

Vadim Yu. Kukushkin, +1 more
- 22 Mar 2002 - 
Journal ArticleDOI

Toward the development of metal-based synthetic nucleases and peptidases: a rationale and progress report in applying the principles of coordination chemistry

Eric L. Hegg, +1 more
- 01 Jun 1998 - 
TL;DR: Recently, there has been a great interest in designing small metal complexes which are capable of catalytically hydrolyzing deoxyribonucleic acid (DNA), ribonuclear acid (RNA), and protein this article.
Journal ArticleDOI

Structure and Nuclease Activity of Simple Dinuclear Metal Complexes: Quantitative Dissection of the Role of Metal Ions

Nicholas H. Williams, +3 more
- 29 Jan 1999 - 
References
More filters
Journal ArticleDOI

Why nature chose phosphates

Frank H. Westheimer
- 06 Mar 1987 - 
TL;DR: Stable, negatively charged phosphates react under catalysis by enzymes; organic chemists, who can only rarely use enzymatic catalysis for their reactions, need more highly reactive intermediates than phosphates.
Journal ArticleDOI

A small catalytic oligoribonucleotide

Olke C. Uhlenbeck
- 01 Aug 1987 - 
TL;DR: A 19-nucleotide RNA fragment can cause rapid, highly specific cleavage of a 24-nuclear RNA fragment under physiological conditions.
Journal ArticleDOI

Nuclease activity of 1,10-phenanthroline-copper ion

David S. Sigman
- 01 Jun 1986 - 
Journal ArticleDOI

The chemistry of self-splicing RNA and RNA enzymes.

Thomas R. Cech
- 19 Jun 1987 - 
TL;DR: The chemical mechanisms of RNA-catalyzed reactions are discussed with emphasis on the self-splicing ribosomal RNA precursor of Tetrahymena and the enzymatic activities of its intervening sequence RNA.
Journal ArticleDOI

Biochemical topology: applications to DNA recombination and replication.

Steven A. Wasserman, +1 more
- 23 May 1986 - 
TL;DR: Quantitative as well as qualitative characterization is possible for any pathway in which the fate of a circular DNA can be followed.
Related Papers (5)

Structure and Nuclease Activity of Simple Dinuclear Metal Complexes: Quantitative Dissection of the Role of Metal Ions

Nicholas H. Williams, +3 more
- 29 Jan 1999 - 

Roles of zinc(II) ion in phosphatases. A model study with zinc(II)-macrocyclic polyamine complexes

Tohru Koike, +1 more
- 01 Nov 1991 - 

Cobalt(III) complex-promoted hydrolysis of phosphate diesters: comparison in reactivity of rigid cis-diaquo(tetraaza)cobalt(III) complexes

Jik Chin, +3 more
- 01 Jan 1989 - 

Toward the development of metal-based synthetic nucleases and peptidases: a rationale and progress report in applying the principles of coordination chemistry

Eric L. Hegg, +1 more
- 01 Jun 1998 - 

Recent Advances in Zinc Enzymology

William N. Lipscomb, +1 more
- 07 Nov 1996 -