Journal ArticleDOI
Development of directly coupled supercritical fluid chromatography with packed capillary column-mass spectrometry with atmospheric pressure chemical ionization
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Semi-micro packed column supercritical fluid chromatography was combined with atmospheric pressure chemical ionization mass spectrometry through a vacuum nebulization interface originally developed for high-performance liquid chromatography (HPLC).About:
This article is published in Journal of Chromatography A.The article was published on 1992-07-10. It has received 26 citations till now. The article focuses on the topics: Supercritical fluid chromatography & Direct electron ionization liquid chromatography–mass spectrometry interface.read more
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Journal ArticleDOI
Supercritical Fluid Chromatography and Extraction
Journal ArticleDOI
Supercritical fluid extraction and chromatography for fat-soluble vitamin analysis.
TL;DR: This review gives a brief description of suitable supercritical media as well as basic theory on SFE and SFC processes, and guidelines for optimizing the important extraction and separation parameters to facilitate a successful method development.
Reference BookDOI
Chromatographic Analysis of Pharmaceuticals
TL;DR: Regulatory Considerations for the Chromatographer, John A. Adamovics and James C. Eschbach High-Performance Liquid Chromatography.
Journal ArticleDOI
SFC/MS in drug discovery at Pfizer, La Jolla
Ben Bolaños,Michael J. Greig,Manuel Ventura,William Farrell,Christine Aurigemma,Haitao Li,Terri Quenzer,Kathleen Tivel,Jessica M. R. Bylund,Phuong Tran,Catherine Pham,Doug Phillipson +11 more
TL;DR: The use of supercritical fluid chromatography/mass spectrometry for numerous applications in drug discovery at Pfizer, La Jolla has been heavily relied upon for analysis and purification of a diverse set of compounds from the in-house chemical library.
Journal ArticleDOI
Capillary supercritical fluid chromatography combined with atmospheric pressure chemical ionisation mass spectrometry for the investigation of photoproduct formation in the sunscreen absorber 2-ethylhexyl-p-methoxycinnamate
JK Broadbent,Bice S. Martincigh,Mark W. Raynor,L.F. Salter,Robert Moulder,Per J. R. Sjöberg,Karin E. Markides +6 more
TL;DR: The photoproducts formed on ultraviolet irradiation of the sunscreen absorber trans-2-ethylhexyl-p-methoxycinnamate, were separated and characterised using a new combined technique, capillary supercritical fluid chromatography-atmospheric pressure chemical ionisation mass spectrometry as mentioned in this paper.
References
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Journal ArticleDOI
Packed-column supercritical fluid chromatography—mass spectrometry and supercritical fluid chromatography—tandem mass spectrometry with ionization at atmospheric pressure
TL;DR: In this paper, a combination of packed-column supercritical fluid chromatography with atmospheric pressure ionization mass spectrometry (SFC-API-MS) is reported, in which the adiabatic expansion of total SFC effluent is subjected to atmospheric pressure chemical ionization (APCI) via a corona discharge with the aid of a heated region around the restrictor.
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Direct heated interface probe for capillary supercritical fluid chromatography/double focusing mass spectrometry
TL;DR: In this article, a capillary supercritical fluid chromatograph was occupied to a double focusing mass spectrometer with a direct heated probe interface, which not only preserved the chromatographic efficiency but also provided for mass spectral detection and identification of various high molecular weight, thermally labile, and polar compounds.
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Industrial applications of supercritical-fluid chromatography—mass spectrometry involving oligometric materials of low volatility and thermally labile materials
TL;DR: In this paper, three recent applications of supercritical-fluid chromatography with flame ionization (SFC-FID) and with mass spectrometric detection are discussed.
Journal ArticleDOI
Liquid chromatography/fast-atom-bombardement mass spectrometry of nonionic detergents
TL;DR: In this paper, microcolumn liquid chromatography (LC) combined with fast-atom-bombardment mass spectrometry (FABMS) was applied to the analysis of nonionic detergents.
Journal ArticleDOI
Design and industrial applications of a removable probe interface for direct capillary supercritical-fluid chromatography−mass spectrometry
TL;DR: An interface coupling capillary supercritical-fluid chromatography (SFC) with a commercial quardruppole mass spectromer has been assembled and utilized to investigate problems involving separation and identification in the consumer products industry as discussed by the authors.