Journal ArticleDOI
Dexamethasone suppression test in a pluri‐diagnostic approach: its relationship to psychopathological and clinical variables
S. Kasper,H. Beckmann +1 more
TLDR
The dexamethasone suppression test was studied in 67 depressed inpatients in its relationship to diverse clinical variables using the International Classification of Diseases, Research Diagnostic Criteria, Newcastle Index, and the Hamilton Depression Rating scale.Abstract:
Using a pluridiagnostic approach, the dexamethasone suppression test (DST) was studied in 67 depressed inpatients in its relationship to diverse clinical variables. The International Classification of Diseases (ICD), the Research Diagnostic Criteria (RDC), the Newcastle Index, the Hamilton Depression Rating scale (HAM-D), and the Bf-s self rating questionnaire were applied. Fifty-two per cent of endogenous depressed (ICD), 51% of major depressive (RDC) and 53% of endogenous depressed (Newcastle) patients demonstrated dexamethasone nonsuppression (DSTN) with a value above 110 nm/l. Six per cent of neurotic depressed (ICD), 9% of minor depressive (RDC) and 23% of neurotic depressed (Newcastle) patients were dexamethasone nonsuppressors. Significantly higher values (after P-correction) for DSTN could be detected in severity ratings as measured with Newcastle (P less than 0.001) and HAM-D global score (P less than 0.001) and also for HAM-D factor 4 (somatic complaints, P = 0.001). All the other evaluated variables did not discriminate between patients with dexamethasone suppression and with nonsuppression.read more
Citations
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Journal ArticleDOI
The Dexamethasone Suppression Test for Diagnosis and Prognosis in Psychiatry: Commentary and Review
TL;DR: A modified dexamethasone suppression test (DST) has had unprecedented evaluation among biologic tests proposed for clinical use in psychiatry, but it has not proved to reflect pathophysiologic changes at the level of the central nervous system or pituitary, and tissue availability of dexamETHasone itself may contribute to test outcome.
Journal ArticleDOI
Culture, Affect and Somatization: Part Ii
TL;DR: Systems of health care articulate categories of somatic disease that give the healer a unique way of thinking and acting that reveals conflicts between the basic perceptions and values of healer and sufferer.
Journal ArticleDOI
Melancholic Symptom Features and DSM-IV
A. J. Rush,J E Weissenburger +1 more
TL;DR: The available evidence suggests some clinical utility and some (albeit not entirely consistent) validity for the concept of melancholic features in the diagnosis of the endogenous (melancholic) subtype of major depression.
Journal ArticleDOI
The validity of four definitions of endogenous depression. II. Clinical, demographic, familial, and psychosocial correlates
TL;DR: The validity of the Newcastle scale was the most frequently supported, with the endogenous depressives having a lower rate of personality disorder, marital separations and divorces, familial alcoholism, life events, and nonserious suicide attempts.
Journal ArticleDOI
The dexamethasone suppression test, the Hamilton Depression Rating Scale and the DSM-III depression categories
TL;DR: The patients with major depression were more severely depressed than patients suffering from minor depression and the highest levels of cortisol were significantly correlated with the HDRS score.
References
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