James W. Maas

TL;DR: Pretreatment measures of hypothalamic-pituitary-adrenocortical (HYPAC) function in depressed, manic, and healthy normal subjects showed that nonsuppression on the dexamethasone suppression test (DST) had less positive predictive value for major diagnostic category and was more frequent in normals than recently reported, although it was yet more Frequent in depressed patients.

TL;DR: Patients who responded best excreted greater quantities of normetanephrine and MHPG during drug treament, relative to the predrug period, and those patients who responded least well had a decrement in the excretion of these two metabolities.

TL;DR: The biochemical heterogeneity of human depression has implications for both investigators and clinicians, and may account for disparate findings in biological studies of patients with affective disorders as discussed by the authors, which may explain the disparate findings.

TL;DR: It is shown that wild-type, AC1, AC8, or AC1&8 double knockout mice were indistinguishable in tests of acute pain, whereas behavioral responses to peripheral injection of two inflammatory stimuli, formalin and complete Freund's adjuvant, were reduced or abolished in AC1 &8 DKO mice.

TL;DR: Four truncating mutations involving the gene PRRT2 in the vast majority of well-characterized families with PKD/IC are identified, leading ultimately to neuronal hyperexcitability that manifests in vivo as PKd/IC.