Journal ArticleDOI
Diabetes: treating diabetic nephropathy-still an unresolved issue.
Reads0
Chats0
TLDR
There is no clear-cut evidence showing that intensive glycaemic control reduces the risk of micro albuminuria and macroalbuminuria, but there is noclear-cutEvidence showing that it reduces doubling of serum creatinine levels or risk of death from kidney disease.Abstract:
Whether treatment of hyperglycaemia prevents progression of diabetic nephropathy is controversial. Intensive glycaemic control reduces the risk of microalbuminuria and macroalbuminuria, but there is no clear-cut evidence showing that it reduces doubling of serum creatinine levels or risk of death from kidney disease. Larger studies or further follow-up of previous trials are required to better assess renal outcomes.read more
Citations
More filters
Journal ArticleDOI
Inflammatory Cytokines in Diabetic Nephropathy
Javier Donate-Correa,Ernesto Martín-Núñez,Mercedes Muros-de-Fuentes,Carmen Mora-Fernández,Juan F. Navarro-González +4 more
TL;DR: This review is focused on the inflammatory processes that develop diabetic nephropathy and on the new therapeutic approaches with anti-inflammatory effects for the treatment of chronic kidney disease in the setting of diabetic nerophropathy.
Journal ArticleDOI
Management of diabetic nephropathy: Recent progress and future perspective.
TL;DR: The pathogenesis and some of the well established principles regarding the progression and accepted management of DN are addressed, and the perspectives of novel anti-DN agents and the future directions for the prevention are included.
Journal ArticleDOI
Inflammatory Targets in Diabetic Nephropathy.
Javier Donate-Correa,Desirée Luis-Rodríguez,Ernesto Martín-Núñez,Víctor G. Tagua,Carolina Hernández-Carballo,Carla Ferri,Ana Rodríguez-Rodríguez,Carmen Mora-Fernández,Juan F. Navarro-González +8 more
TL;DR: This review focuses on the pathogenesis of proinflammatory molecules and mechanisms related to the development and progression of DN, and discusses the potential utility of new strategies based on agents that target inflammation.
Journal ArticleDOI
The Signaling of Cellular Senescence in Diabetic Nephropathy
Yabing Xiong,Lili Zhou +1 more
TL;DR: The mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/β-catenin signaling activation, persistent inflammation, and accumulation of uremic toxins are reviewed.
Journal ArticleDOI
Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives
TL;DR: The pathogenesis of DN is summarized and a major context focuses on a few small molecules toward the pathogenesis available in animal models and clinical trials for the treatment of DN.
References
More filters
Journal ArticleDOI
Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
David S. Cooper,Gerard M. Doherty,Bryan R. Haugen,Richard T. Kloos,Stephanie L. Lee,Susan J. Mandel,Ernest L. Mazzaferri,Bryan McIver,Furio Pacini,Martin Schlumberger,Steven I. Sherman,David L. Steward,R. Michael Tuttle +12 more
TL;DR: Evidence-based recommendations in response to the appointment as an independent task force by the American Thyroid Association to assist in the clinical management of patients with thyroid nodules and differentiated thyroid cancer represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Journal ArticleDOI
10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
TL;DR: Despite an early loss of glycemic differences, a continued reduction in microvascular risk and emergent risk reductions for myocardial infarction and death from any cause were observed during 10 years of post-trial follow-up.
Journal ArticleDOI
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes.
David M. Nathan,Patricia A. Cleary,Jye Yu C. Backlund,Saul Genuth,John M. Lachin,Trevor J. Orchard,Philip Raskin,Bernard Zinman +7 more
TL;DR: Intensive diabetes therapy has long-term beneficial effects on the risk of cardiovascular disease in patients with type 1 diabetes, and changes between treatment groups remained significant after adjusting for these factors.
Journal ArticleDOI
Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
TL;DR: Routine administration of a fixed combination of perindopril and indapamide to patients with type 2 diabetes was well tolerated and reduced the risks of major vascular events, including death, which suggest that over 5 years, one death due to any cause would be averted.
Journal ArticleDOI
Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction.
Nagesh S. Anavekar,John J.V. McMurray,Eric J. Velazquez,Scott D. Solomon,Lars Køber,Jean-Lucien Rouleau,Harvey D. White,Rolf Nordlander,Aldo P. Maggioni,Kenneth Dickstein,Steven L. Zelenkofske,Jeffrey D. Leimberger,Robert M. Califf,Marc A. Pfeffer +13 more
TL;DR: Even mild renal disease, as assessed by the estimated GFR, should be considered a major risk factor for cardiovascular complications after a myocardial infarction.