Dibenzothiazepine a break through heterocyclic nucleus in medicinal chemistry

TLDR: In this paper, the authors focused on pharmacological and synthetic profile of dibenzothiazepine, a conjugated heterocyclic ring systems reported for their wide spectrum of pharmacological activity especially for its psychotherapeutic activities.

Abstract: Dibenzothiazepine, a conjugated heterocyclic ring systems reported for their wide spectrum of pharmacological activity especially for its psychotherapeutic activities. Successful introduction of quetiapine, tianeptine, clotiapine for antipsychotic activity along with its evidence for other biological activity proved potential of dibenzothiazepine moiety. Subsequently dibenzodiazepine were highlighted as important biologically active scaffolds. The discovery of quetiapine fumarate as psychotropic agents attracted much attention worldwide. The current review article focuses on pharmacological and synthetic profile of dibenzothiazepine. This article mainly outlines some structural modifications done on dibenzothiazepine to offer newer derivatives with potential biological activity.