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Amaury Farce
Researcher at Lille University of Science and Technology
Publications - 44
Citations - 1045
Amaury Farce is an academic researcher from Lille University of Science and Technology. The author has contributed to research in topics: Farnesyltransferase & Phthalate. The author has an hindex of 14, co-authored 39 publications receiving 905 citations. Previous affiliations of Amaury Farce include Université catholique de Louvain & university of lille.
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Journal ArticleDOI
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.
Christel Rousseaux,Bruno Lefebvre,Laurent Dubuquoy,Philippe Lefebvre,Olivier Romano,Johan Auwerx,Daniel Metzger,Walter Wahli,Béatrice Desvergne,Gian Carlo Naccari,Philippe Chavatte,Amaury Farce,Philippe Bulois,Antoine Cortot,Jean-Frederic Colombel,Pierre Desreumaux +15 more
TL;DR: PPAR-γ is identified as a target of 5-ASA underlying antiinflammatory effects in the colon, and its activities are associated with the recruitment of coactivators and the activation of a peroxisome-proliferator response element–driven gene.
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Novel 4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New CB2 Cannabinoid Receptors Agonists: Synthesis, Pharmacological Properties and Molecular Modeling
Eric Stern,Giulio G. Muccioli,Régis Millet,Jean-François Goossens,Amaury Farce,Philippe Chavatte,Jacques H. Poupaert,Didier M. Lambert,Patrick Depreux,Jean‐Pierre Henichart +9 more
TL;DR: 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives constitute a new class of potent and selective CB(2) cannabinoid receptors agonists.
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Docking Study of Ligands into the Colchicine Binding Site of Tubulin
Amaury Farce,Cédric Logé,Sebastien Gallet,Nicolas Lebegue,Pascal Carato,Philippe Chavatte,Pascal Berthelot,Daniel Lesieur +7 more
TL;DR: The characterization of the binding site of colchicine seems to lie between the two units of the tubulin dimer, and this site is characterized by the docking of a series of reference compounds, and the subsequent docking of ligands prepared in the laboratory.
Journal ArticleDOI
New farnesyltransferase inhibitors in the phenothiazine series.
Dalila Belei,Carmen Dumea,Alexandrina Samson,Amaury Farce,Joëlle Dubois,Elena Bîcu,Alina Ghinet +6 more
TL;DR: The modest results obtained in this preliminary investigation showed that mixing the phenothiazine and the 1,2,3-triazole motif in the structure of a single compound can lead to new scaffolds in the field of farnesyltransferase inhibitors.
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Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors
Pauline Gilleron,Nicolas Wlodarczyk,Raymond Houssin,Amaury Farce,Guillaume Laconde,Jean-François Goossens,Amélie Lemoine,Nicole Pommery,Jean-Pierre Hénichart,Régis Millet +9 more
TL;DR: A new series of FTase inhibitors containing a tricyclic moiety--dioxodibenzothiazepine or dibenzocycloheptane--has been designed and synthesized and displayed significant inhibitory FTase activity and antiproliferative properties.