Differences in mitochondrial efficiency explain individual variation in growth performance
Karine Salin,Eugenia M. Villasevil,Graeme J. Anderson,Simon G. Lamarre,Chloé A Melanson,Ian D. McCarthy,Colin Selman,Neil B. Metcalfe +7 more
TLDR
It is shown for the first time, to the authors' knowledge, that among-individual variation in the efficiency with which substrates are converted into ATP can help explain marked variation in growth performance, independent of food intake.Abstract:
The physiological causes of intraspecific differences in fitness components such as growth rate are currently a source of debate. It has been suggested that differences in energy metabolism may drive variation in growth, but it remains unclear whether covariation between growth rates and energy metabolism is: (i) a result of certain individuals acquiring and consequently allocating more resources to growth, and/or is (ii) determined by variation in the efficiency with which those resources are transformed into growth. Studies of individually housed animals under standardized nutritional conditions can help shed light on this debate. Here we quantify individual variation in metabolic efficiency in terms of the amount of adenosine triphosphate (ATP) generated per molecule of oxygen consumed by liver and muscle mitochondria and examine its effects, both on the rate of protein synthesis within these tissues and on the rate of whole-body growth of individually fed juvenile brown trout (Salmo trutta) receiving either a high or low food ration. As expected, fish on the high ration on average gained more in body mass and protein content than those maintained on the low ration. Yet, growth performance varied more than 10-fold among individuals on the same ration, resulting in some fish on low rations growing faster than others on the high ration. This variation in growth for a given ration was related to individual differences in mitochondrial properties: a high whole-body growth performance was associated with high mitochondrial efficiency of ATP production in the liver. Our results show for the first time, to our knowledge, that among-individual variation in the efficiency with which substrates are converted into ATP can help explain marked variation in growth performance, independent of food intake. This study highlights the existence of inter-individual differences in mitochondrial efficiency and its potential importance in explaining intraspecific variation in whole-animal performance.read more
Citations
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Integrating Mitochondrial Aerobic Metabolism into Ecology and Evolution
Rebecca E. Koch,Katherine L. Buchanan,Stefania Casagrande,Ondi L. Crino,Damian K. Dowling,Geoffrey E. Hill,Wendy R. Hood,Matthew McKenzie,Mylene M. Mariette,Daniel W. A. Noble,Alexandra Pavlova,Frank Seebacher,Paul Sunnucks,Eve Udino,Craig R. White,Karine Salin,Antoine Stier,Antoine Stier +17 more
TL;DR: In this article, the authors explore how mitochondrial aerobic metabolism influences different aspects of organismal performance, such as through changing adenosine triphosphate (ATP) and reactive oxygen species (ROS) production.
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What do warming waters mean for fish physiology and fisheries
TL;DR: The principal mechanisms that transduce temperature signals, and the physiological responses to those signals in fish are reviewed.
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Climate change and ageing in ectotherms.
TL;DR: The potential impact of global warming on ectotherm ageing is explored through its effects on reactive oxygen species production, oxidative damage, and telomere shortening, at the individual and intergenerational levels.
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Mitochondrial behaviour, morphology, and animal performance
Kyle B. Heine,Wendy R. Hood +1 more
TL;DR: Future research should focus on how inter‐mitochondrial junctions and morphology of the inner mitochondrial membrane, in particular, influence animal performance in accordance with mitochondrial density, fission, and fusion.
Journal ArticleDOI
How telomere dynamics are influenced by the balance between mitochondrial efficiency, reactive oxygen species production and DNA damage
Neil B. Metcalfe,Mats Olsson +1 more
TL;DR: In this paper, the authors describe how ROS production, rates of damage to telomeric DNA and DNA repair are dynamic processes, and argue that the optimal solution to the trade-off between energetic efficiency and telomere protection will differ between individuals and will change over time, depending on resource availability, energetic demands and life history strategy.
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