Differential Impact of Symptom Prevalence and Chronic Conditions on Quality of Life in Cancer Survivors and Non-Cancer Individuals: A Population Study.
Reads0
Chats0
TLDR
Cancer survivors experience more symptom burden than non-cancer individuals, which is associated with more chronic conditions and impaired HRQOL, and interventions to manage symptom prevalence especially for older cancer survivors and survivors with more Chronic conditions may improve theirHRQOL outcomes.Abstract:
Background: To compare associations of symptom prevalence, chronic conditions, and health-related quality of life (HRQOL) between cancer survivors and non-cancer individuals using the U.S. National Health Interview Survey.Methods: Study samples comprised 604 survivors and 6,166 non-cancer individuals. Symptoms included sensation abnormality, pain, fatigue, cognitive disturbance, depression, and anxiety. Physical and mental HRQOL was measured by the Patient-Reported Outcomes Measurement Information System.Results: Compared with non-cancer individuals, survivors had higher prevalence in sensation abnormality (OR = 2.4; 95% CI = 1.9 to 3.0), pain (OR = 2.1; 95% CI = 1.7 to 2.6), fatigue (OR = 1.4; 95% CI = 1.1 to 1.8), and decremented physical HRQOL (difference = -3.7; 95% CI = -4.7 to -2.6). The prevalence of individual symptoms was significantly associated with decremented physical HRQOL [range = -5.9 (anxiety) to -8.9 (pain)] and mental HRQOL [range = -4.7 (sensation) to -8.4 (depression)]. The association between cancer experience and physical and mental HRQOL was chiefly explained by the prevalence of six symptoms and presence of chronic conditions. Pain (β = -4.0; 95% CI = -4.5 to -3.6) and ≥2 chronic conditions (β = -9.2; 95% CI = -10.2 to -8.2) significantly decremented physical HRQOL. Depression (β = -5.2; 95% CI = -5.8 to -4.6) and ≥2 chronic conditions (β = -3.3; 95% CI = -4.4 to -2.3) significantly decremented mental HRQOL.Conclusions: Cancer survivors experience more symptom burden than non-cancer individuals, which is associated with more chronic conditions and impaired HRQOL.Impacts: Interventions to manage symptom prevalence especially for older cancer survivors and survivors with more chronic conditions may improve their HRQOL outcomes. Cancer Epidemiol Biomarkers Prev; 26(7); 1124-32. ©2017 AACR.read more
Citations
More filters
Journal ArticleDOI
A systematic review of rehabilitation and exercise recommendations in oncology guidelines
Nicole L. Stout,Nicole L. Stout,Daniel Santa Mina,Daniel Santa Mina,Kathleen Doyle Lyons,Kathleen Doyle Lyons,Karen Robb,Julie K. Silver +7 more
TL;DR: Findings identify guidelines that recommend rehabilitation services across many cancer types and for various consequences of cancer treatment signifying that rehabilitation is a recognized component of oncology care, at odds with clinical reports of low rehabilitation utilization rates suggesting that guideline recommendations may be overlooked.
Journal ArticleDOI
Integration of Massage Therapy in Outpatient Cancer Care.
Virginia S. Cowen,Barbara Tafuto +1 more
TL;DR: The findings of this analysis suggest that research on massage is not being leveraged to integrate massage into outpatient cancer care at NCI-designated Cancer Centers.
Journal ArticleDOI
Association Between Symptom Burden and Physical Function in Older Patients with Cancer
Chintan Pandya,Allison Magnuson,Marie Flannery,Jason Zittel,Paul R. Duberstein,Kah Poh Loh,Erika Ramsdale,Nikesha Gilmore,William Dale,Supriya G. Mohile +9 more
TL;DR: To evaluate the independent association between symptom burden and physical function impairment in older adults with cancer, a large number of patients with cancer were randomly assigned to a smoking or non-smoking group.
Journal ArticleDOI
Effects of a physical activity programme to prevent physical performance decline in onco‐geriatric patients: a randomized multicentre trial
Haritz Arrieta,Haritz Arrieta,Haritz Arrieta,Cyril Astrugue,Sophie C. Regueme,Jessica Durrieu,Aline Maillard,Alban Rieger,Eric Terrebonne,Christophe Laurent,Brigitte Maget,V. Servent,Sandrine Lavau-Denes,Jérôme Dauba,Marianne Fonck,Rodolphe Thiébaut,Isabelle Bourdel-Marchasson,Isabelle Bourdel-Marchasson +17 more
TL;DR: Older adults with cancer experience negative long‐term functional effects of both cancer and treatments, and exercise may minimize their age‐related and cancer‐related functional decline.
Journal ArticleDOI
Chronic pain, health-related quality of life, and employment in working-age cancer survivors.
TL;DR: Cancer-related chronic pain is a prevalent, long-term condition that is negatively associated with HRQoL and employment in working-age cancer survivors and employment outcomes, particularly in women.
References
More filters
Journal ArticleDOI
Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes
Ira B. Wilson,Paul D. Cleary +1 more
TL;DR: This model proposes a taxonomy or classification scheme for different measures of health outcome, dividing these outcomes into five levels: biological and physiological factors, symptoms, functioning, general health perceptions, and overall quality of life.
Journal ArticleDOI
The patient-reported outcomes measurement information system (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008
David Cella,William T. Riley,Arthur A. Stone,Nan E. Rothrock,Bryce B. Reeve,Susan Yount,Dagmar Amtmann,Rita K. Bode,Daniel J. Buysse,Seung W. Choi,Karon F. Cook,Robert F. DeVellis,Darren A. DeWalt,James F. Fries,Richard Gershon,Elizabeth A. Hahn,Jin Shei Lai,Paul A. Pilkonis,Dennis A. Revicki,Matthias Rose,Kevin P. Weinfurt,Ron D. Hays +21 more
TL;DR: The first large-scale testing of PROMIS item banks and their short forms provide evidence that they are reliable and precise measures of generic symptoms and functional reports comparable to legacy instruments.
Journal ArticleDOI
Cancer treatment and survivorship statistics, 2014
Carol DeSantis,Chun Chieh Lin,Angela B. Mariotto,Rebecca L. Siegel,Kevin Stein,Joan L. Kramer,Rick Alteri,Anthony S. Robbins,Ahmedin Jemal +8 more
TL;DR: The number of cancer survivors continues to increase due to the aging and growth of the population and improvements in early detection and treatment, and current treatment patterns for the most common cancer types are described based on information in the National Cancer Data Base and the SEER and SEER‐Medicare linked databases.
Journal ArticleDOI
Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial.
Ethan Basch,Allison M. Deal,Mark G. Kris,Howard I. Scher,Clifford A. Hudis,Paul Sabbatini,Lauren J. Rogak,Antonia V. Bennett,Amylou C. Dueck,Thomas M. Atkinson,Joanne F. Chou,Dorothy Dulko,Laura Sit,Allison Barz,Paul J. Novotny,Michael Fruscione,Jeff A. Sloan,Deborah Schrag +17 more
TL;DR: Clinical benefits were associated with symptom self-reporting during cancer care and were greater for participants lacking prior computer experience.
Journal ArticleDOI
Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items
TL;DR: Two dimensions representing physical and mental health underlie the global health items in PROMIS and these global health scales can be used to efficiently summarize physical andmental health in patient-reported outcome studies.