Journal ArticleDOI
Dihydrotestosterone formation in fetal tissues of the rabbit and rat.
Jean D. Wilson,Ilse Lasnitzki +1 more
Reads0
Chats0
TLDR
The findings suggest that the capacity to form dihydrotestosterone in urogenital sinus and tubercle is not the result of androgen action but rather an inherent or obligatory property of the tissue and may fulfill in part the function of an initial androgen receptor in these organs.Abstract:
The rate of conversion of testosterone- l,2-3H to dihydrotestosterone-3H has been measured in a variety of tissues in rabbit embryos from 17 days of development to 3 days following birth and in rat embryos from 15 days of gestation to 4 days after delivery. In the rabbit embryo dihydrotestosterone formation was rapid only in the urogenital sinus and urogenital tubercle of both sexes at the earliest stages studied and was not measurable in wolffian and mullerian ducts until after gender identification was easily demonstrable. A similar pattern of development was observed in the rat embryo. These findings suggest that the capacity to form dihydrotestosterone in urogenital sinus and tubercle is not the result of androgen action but rather an inherent or obligatory property of the tissue and may fulfill in part the function of an initial androgen receptor in these organs. In contrast, in the mullerian and wolffian ducts the ability to form dihydrotestosterone appears to be acquired after the initial stages of...read more
Citations
More filters
Journal ArticleDOI
Steroid 5 alpha-reductase 2 deficiency.
TL;DR: In the 20 years since it was established that impairment of dihydrotestosterone formation is the cause of a rare form of human intersex, a wealth of information has accumulated about the genetics, endocrinology, and variable phenotypic manifestations, culminating in the cloning of cDNAs encoding two 5 alpha-reductase genes.
Book ChapterDOI
Physiology of Reproduction
TL;DR: In order to observe sexual behavior in rats, a male rat that has already been trained to mate with normal females several times is placed in a test cage under a red dim light and a steroid-induced estrous female is introduced.
Journal ArticleDOI
Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.
Patrick C. Walsh,James D. Madden,Mary Jo Harrod,Joseph L. Goldstein,Paul C. MacDonald,Jean D. Wilson +5 more
TL;DR: The demonstration of markedly deficient dihydrotestosterone formation in slices of perineal skin, epididymis and phallus, is compatible with the fact that dihydotestosterone is the fetal hormone responsible for male differentiation of the external genitalia, iscompatible with the idea that androgen resistance in this syndrome is different from that in other androgen-resistant states.
Book ChapterDOI
Studies on sex differentiation in mammals.
TL;DR: The evidence of the freemartins suggests that presumptive ovaries, if submitted to an appropriate influence, probably the two kinds of fetal testicular hormones, still may develop testicle-like structures in the place of ovarian follicles.
Journal ArticleDOI
Steroid 5α-Reductase 2 Deficiency
TL;DR: It is imperative to establish whether defects in steroid 5 alpha-reductase 2, perhaps in the heterozygous state, are responsible for a portion of cases of sporadic hypospadias, to determine whether 5alpha- reductase plays a role in progesterone action in women, and to elucidate the relation between androgen action and gender role behavior.
References
More filters
Book
Androgens: Biochemistry, Physiology, and Clinical Significance.
TL;DR: On her discharge from hospital in October, 1955, there remained only bilateral extensor paresis, and she was walking with short leg calipers and extensionsprings.
Related Papers (5)
Testosterone Formation and Metabolism During Male Sexual Differentiation in the Human Embryo
Pentti K. Siiteri,Jean D. Wilson +1 more