Dipole moment of alamethicin as related to voltage-dependent conductance in lipid bilayers.
TLDR
The calculated value of the dipole moment was found to be larger than the value of direct measurements, indicating that several alamethicin molecules are required to form a conducting pore and that their dipole moments are oriented parallel to each other.Citations
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Journal ArticleDOI
Model ion channels: gramicidin and alamethicin.
G A Woolley,Bonnie A. Wallace +1 more
TL;DR: Experimental studies designed to elucidate the conformational and dynamic properties of gramicidin and alamethicin have already permitted aspects of ion channel activity to be understood in molecular terms, and simulations of ion transport using computational methods are likely to improve and will further the understanding of the processes of ions transport.
Journal ArticleDOI
Alamethicin. A rich model for channel behavior
TL;DR: A channel structure in which the COOH-terminal residues bond together as a beta-barrel, leaving the alpha- helices free to rotate under the influence of the electric field and gate the channel.
Journal ArticleDOI
Alamethicin incorporation in lipid bilayers: a thermodynamic study.
TL;DR: From the results obtained in this study, one can extrapolate to the incorporation behavior of alamethicin at low concentrations, as they are typical for measurements of conductance across planar lipid films, which leads to a simple explanation of the voltage-gating mechanism ofAlamethiin in a straightforward way.
Journal ArticleDOI
Alamethicin pore formation: Voltage-dependent flip-flop of α -helix dipoles
TL;DR: This model is consistent with published data and with two additional experimental facts, that pore state distributions are ionic strength dependent and poreState conductances depend on ionic current direction.
References
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Journal ArticleDOI
Conformational Changes of Alamethicin Induced by Solvent and Temperature
TL;DR: In this paper, a model illustrating the dynamic conformations and aggregation phenomena within a membrane is proposed, based on the 13C NMR and circular dichroism (CD) spectra of alamethicin.
Journal ArticleDOI
Potential-Dependent Conductances in Lipid Membranes Containing Alamethicin
L.G.M. Gordon,D.A. Haydon +1 more
TL;DR: It is proposed that the conducting complex is capable of functioning in either of two orientations, and that it is these two possibilities that give rise to certain differences in the single channel characteristics for the two directions of the field.
Journal ArticleDOI
Conformation and molecular mechanisms of carriers and channels.
TL;DR: Transmembrane structures capable of forming channels are commonly constructed of repeating units, and the conformations of two carriers extrapolate readily to structures that are capable of spanning the lipid layer to form channels.
Book ChapterDOI
Bimolecular Lipid Membranes: Techniques of Formation, Study of Electrical Properties, and Induction of Ionic Gating Phenomena
P. Mueller,D. O. Rudin +1 more
TL;DR: Bimolecular membranes formed from cellular lipids have many properties of cell membranes and have the same values for thickness, electrical capacitance, dielectric strength, water permeability and surface tension.