Journal ArticleDOI
Direct N-alkylation of sulfur-containing amines.
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TLDR
An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy as discussed by the authors.Abstract:
An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy. The present methodology features base-free conditions and broad substrate scope, with water being the only by-product. Moreover, this protocol has been applied to the synthesis of the pharmaceutical drug Quetiapine.read more
Citations
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Direct Synthesis of Amides from Benzonitriles and Benzylic Alcohols via a KOt-Bu-Mediated MPV-type Hydrogen Transfer Process.
TL;DR: Meerwein-Ponndorf-Verley (MPV)-type reduction between benzonitriles and benzylic alcohols under transition-metal-free conditions has been demonstrated for the first time in this paper .
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Base-controlled chemoselectivity: direct coupling of alcohols and acetonitriles to synthesise α-alkylated arylacetonitriles or acetamides
TL;DR: In this paper, a phosphine-free ligand α,α,α-terpyridine showed high catalytic performance in chemodivergent synthesis of α-alkylated arylacetonitriles.
References
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Journal ArticleDOI
General Synthesis of N-Alkylation of Amines with Secondary Alcohols via Hydrogen Autotransfer.
TL;DR: Preliminary mechanistic studies suggest that the N-alkylation reaction proceeds via a hydrogen autotransfer mechanism, and the reaction operates under mild, benign conditions.
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Nickel(II)-NΛNΛO Pincer Type Complex-Catalyzed N-alkylation of Amines with Alcohols via the Hydrogen Autotransfer Reaction.
TL;DR: The inexpensive nickel based catalytic methodology displays a broad substrate scope for the N-alkylation of aromatic and heteroaromatic amines using a diverse range of primary alcohols with excellent yields up to 97%.
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Solvent-free direct α-alkylation of ketones by alcohols catalyzed by nickel supported on silica–alumina
TL;DR: In this article, the α-alkylation of acetophenone with benzyl alcohol through borrowing hydrogen has been studied using nickel catalysis and the Ni/SiO2-Al2O3 was found to be the best catalyst for this transformation.
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Mitsunobu Reaction Using Basic Amines as Pronucleophiles.
Hai Huang,Jun Yong Kang +1 more
TL;DR: A novel protocol for extending the scope of the Mitsunobu reaction to include amine nucleophiles to form C-N bonds through the utilization of N-heterocyclic phosphine-butane (NHP- butane) has been developed.
Journal ArticleDOI
Adsorption of thiophene on transition metal surfaces with the inclusion of van der Waals effects
TL;DR: In this article, the authors used density functional theory with the inclusion of the van der Waals interaction to study the adsorption of thiophene, C4H4S, on Pt, Rh, Pd, Au, and Ag (100) surfaces.