Journal ArticleDOI
Direct N-alkylation of sulfur-containing amines.
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TLDR
An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy as discussed by the authors.Abstract:
An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy. The present methodology features base-free conditions and broad substrate scope, with water being the only by-product. Moreover, this protocol has been applied to the synthesis of the pharmaceutical drug Quetiapine.read more
Citations
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Direct Synthesis of Amides from Benzonitriles and Benzylic Alcohols via a KOt-Bu-Mediated MPV-type Hydrogen Transfer Process.
TL;DR: Meerwein-Ponndorf-Verley (MPV)-type reduction between benzonitriles and benzylic alcohols under transition-metal-free conditions has been demonstrated for the first time in this paper .
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Base-controlled chemoselectivity: direct coupling of alcohols and acetonitriles to synthesise α-alkylated arylacetonitriles or acetamides
TL;DR: In this paper, a phosphine-free ligand α,α,α-terpyridine showed high catalytic performance in chemodivergent synthesis of α-alkylated arylacetonitriles.
References
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Journal ArticleDOI
The Catalytic Amination of Alcohols
TL;DR: In this article, the synthesis of amines by the amination of alcohols, by means of the so-called borrowing hydrogen methodology, is presented Compared to other synthetic methodologies for the synthesis, these transformations are highly attractive because often alcohols are readily available starting materials, some of them on a large scale from renewable sources.
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Ruthenium-catalyzed N-alkylation of amines and sulfonamides using borrowing hydrogen methodology.
M. Haniti S. A. Hamid,C. Liana Allen,Gareth W. Lamb,Aoife C. Maxwell,Hannah C. Maytum,Andrew Watson,Jonathan M. J. Williams +6 more
TL;DR: The alkylation of amines by alcohols has been achieved using 0.5 mol % [Ru(p-cymene)Cl(2)](2) with the bidentate phosphines dppf or DPEphos as the catalyst.
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The Give and Take of Alcohol Activation
TL;DR: Alcohols are relatively common starting materials for chemical reactions, even though they are quite unreactive, and are usually activated by turning the hydroxide into a better leaving group, either by protonating the alcohol or by converting it into a sulfonate or halide.
Journal ArticleDOI
3d-Metal Catalyzed N- and C-Alkylation Reactions via Borrowing Hydrogen or Hydrogen Autotransfer
Torsten Irrgang,Rhett Kempe +1 more
TL;DR: The findings in this field are expected to inspire others to develop new efficient and selective earth-abundant metal catalysts for borrowing hydrogen or hydrogen autotransfer applications or to develop novel alcohol refunctionalization reactions that can be mediated by such metals.
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The Reductive Amination of Aldehydes and Ketones and the Hydrogenation of Nitriles: Mechanistic Aspects and Selectivity Control
TL;DR: In this paper, a review of two of the most commonly used methods for the preparation of amines: reductive amination of aldehydes and ketones and the hydrogenation of nitriles is presented.