DNAzyme-Functionalized Nanomaterials: Recent Preparation, Current Applications, and Future Challenges.
Jabrane Jouha,Hai Xiong +1 more
TLDR
In this article, a review of DNAzyme-nanomaterial bioconjugates with metal-organic frameworks (MOFs), gold nanoparticles (AuNPs), graphene oxide (GO), and molybdenum disulfide (MoS2) is presented.Abstract:
DNAzyme-nanomaterial bioconjugates are a popular hybrid and have received major attention for diverse biomedical applications, such as bioimaging, biosensor development, cancer therapy, and drug delivery. Therefore, significant efforts are made to develop different strategies for the preparation of inorganic and organic nanoparticles (NPs) with specific morphologies and properties. DNAzymes functionalized with metal-organic frameworks (MOFs), gold nanoparticles (AuNPs), graphene oxide (GO), and molybdenum disulfide (MoS2 ) are introduced and summarized in detail in this review. Moreover, the focus is on representative examples of applications of DNAzyme-nanomaterials over recent years, especially in bioimaging, biosensing, phototherapy, and stimulation response delivery in living systems, with their several advantages and drawbacks. Finally, the perspective regarding the future directions of research addressing these challenges is also discussed and highlighted.read more
Citations
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Oxidase-mimicking peptide-copper complexes and their applications in sandwich affinity biosensors.
TL;DR: In this paper , the peptide-Cu2+ complexes reveal oxidase-mimicking activities for oxygen reduction and ascorbate oxidation, which can be easily integrated with nanomaterials such as gold nanoparticles to form nanocatalysts or nanozymes, which allows for the fabrication of sensitive sensing platforms.
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Spatiotemporally Controlled Ultrasensitive Molecular Imaging Using a DNA Computation-Mediated DNAzyme Platform.
Dan-dan Li,Tingting Zhao,Jing M. Chen,Jiaheng Shi,Junhao Wang,Yue Yin,Shuwei Chen,Shenghao Xu,Xiliang Luo +8 more
TL;DR: A DNA computation-mediated DNAzyme platform that can be activated by 808 nm NIR light and target c-MYC was designed for spatiotemporally controlled ultrasensitive AND-gated molecular imaging.
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Ultrasenstive SERS biosensor based on Zn2+ from ZnO nanoparticle assisted DNA enzyme amplification for detection of miRNA.
TL;DR: In this paper , a simple and sensitive SERS biosensor was proposed for ultrasensitive detecting miRNA 122 based on ZnO nanoparticle amplification strategy and the full utilization of DNA chain.
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Materialistic Interfaces with Nucleic Acids: Principles and Their Impact
TL;DR: A deep materialistic background based on the interaction of nucleic acids with these non‐nucleic acid‐based materials covering comprehensive topics is provided, showing their materialistic flexibility and potential and the prospect of forming new future materials.
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Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl
TL;DR: In this article , the authors summarize DNAzyme-based biosensors for the quantitative detection of uranyl ions by integrating with diverse signal outputting strategies, such as fluorescent, colorimetry, surfaceenhanced Raman scattering, and electrochemistry.
References
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Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
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