Journal ArticleDOI
Donor-acceptor-substituted cyclopropane derivatives and their application in organic synthesis.
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This article is published in Chemical Reviews.The article was published on 2003-02-21. It has received 1211 citations till now. The article focuses on the topics: Organic synthesis & Cyclopropane.read more
Citations
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Catalytic C-C bond-forming multi-component cascade or domino reactions: pushing the boundaries of complexity in asymmetric organocatalysis.
Journal ArticleDOI
A new golden age for donor-acceptor cyclopropanes.
TL;DR: This Review highlights the appropriate tools for successfully employing donor-acceptor cyclopropanes in ring-opening reactions, cycloadditions, and rearrangements.
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Heterocycles from cyclopropanes: applications in natural product synthesis
Cheryl A. Carson,Michael A. Kerr +1 more
TL;DR: This tutorial review focuses on the latter, describing recent developments and applications of cyclopropane ring-expansion reactions in natural product synthesis and several newly developed methods providing access to densely functionalized heterocycles.
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Recent studies on the reactions of α-diazocarbonyl compounds
Zhenhua Zhang,Jianbo Wang +1 more
TL;DR: New developments of various reactions of α-diazocarbonyl compounds have been reviewed in this article, which primarily focuses on the literatures published since 2003, focusing on the literature published in 2003.
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Recent advances in donor-acceptor (DA) cyclopropanes
Ming Yu,Brian L. Pagenkopf +1 more
References
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Target-oriented and diversity-oriented organic synthesis in drug discovery.
TL;DR: Several synthetic planning principles for diversity-oriented synthesis and their role in the drug discovery process are presented in this review.
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Recent Advances in Asymmetric Catalytic Metal Carbene Transformations.
Michael P. Doyle,David C. Forbes +1 more
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Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way
TL;DR: Over the last five years, industrial and academic researchers have made the unique exploratory power of some reactions into one of the most efficient and cost-effective tools for combinatorial and parallel synthesis.
Journal ArticleDOI
Mechanism-based target identification and drug discovery in cancer research
TL;DR: There has been a tremendous increase in the authors' knowledge of the molecular mechanisms and pathophysiology of human cancer, and many of these mechanisms have been exploited as new targets for drug development in the hope that they will have greater antitumor activity with less toxicity to the patient.
Journal ArticleDOI
Chiral semicorrins and related nitrogen heterocycles as ligands in asymmetric catalysis
TL;DR: The number of efficient, truly useful enantioselective catalysts is still limited as discussed by the authors, and the main efforts of future research will continue to focus on the improvement of existing methods and on the search for new catalysts.
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Heterocycles from cyclopropanes: applications in natural product synthesis
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